Evidence map›Paper›PMID 38289775›Full record

ArticleJNMA; journal of the Nepal Medical Association2023

Primary Systemic Amyloidosis: A Case Report.

Saurav Sen Oli, Abhishek Jha, Anisha Karki, Shova Sapkota, Laxman Adhikari

Open access · diamondAbstract readCase Reports
In one paragraph

Article in JNMA; journal of the Nepal Medical Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Saurav Sen OliKathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Abhishek JhaKathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Anisha KarkiKathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Shova SapkotaKathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Laxman AdhikariDepartment of Nephrology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Kathmandu Medical College Teaching Hospital · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary systemic amyloidosis is a systemic disease characterised by the deposition of misfolded proteins extracellularly in different organs without any known cause in the background, eventually leading to multiorgan dysfunction and death. The incidence of primary amyloidosis is estimated at 5.1-12.8 cases per million, with a poor prognosis. We report a case of a 69-year male with lower back pain, shortness of breath, and anasarca diagnosed as primary systemic amyloidosis by serum-free light chain assay and kidney needle biopsy. He was started on intravenous bortezomib and dexamethasone. Though he adhered to his medications, with time he developed renal insufficiency marked by azotemia following which hemodialysis was performed. Primary systemic amyloidosis is a rare clinical condition with a very poor prognosis. Further studies are needed to understand the proper pathophysiology and treatment of the disease. Keywords: cardiomyopathies; case reports; primary amyloidosis.

Indexed as

AmyloidosisImmunoglobulin Light-chain AmyloidosisRenal InsufficiencyBortezomibHumansMalePrognosisBortezomib

Identifiers

PMID38289775
PMCPMC10579773
OpenAlexW4387262826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.