Evidence map›Paper›PMID 38289602›Full record

Trial reportJAMA network open2024

Mobile Critical Care Recovery Program for Survivors of Acute Respiratory Failure: A Randomized Clinical Trial.

Babar A Khan, Anthony J Perkins, Sikandar Hayat Khan, Frederick W Unverzagt, Sue Lasiter, Sujuan Gao, Sophia Wang, Ben L Zarzaur, Omar Rahman, Ahmed Eltarras and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in JAMA network open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03053245 (Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03053245 nacompletednot on this map

Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors

TypeinterventionalSponsorIndiana UniversityRan2017 to 2022Enrolled503ConditionsAcute Respiratory Failure, Post-Intensive Care SyndromeArmsMobile Critical Care Program, Attention Control
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Trial
  5. Observational
  6. Article
  7. Rurality and long-term outcomes after critical illness.Annals of the American Thoracic Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Language Barriers and Other Determinants of Post-Intensive Care Unit Follow-Up: A 5-Year Review.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. ICU Recovery Interventions: Is It Time for a Personalized Medicine Approach?American journal of respiratory and critical care medicine · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Babar A KhanDepartment of Medicine, Indiana University School of Medicine, Indianapolis.
Anthony J PerkinsDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis.
Sikandar Hayat KhanDepartment of Medicine, Indiana University School of Medicine, Indianapolis.
Frederick W UnverzagtDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis.
Sue LasiterSchool of Nursing and Health Sciences, University of Missouri, Kansas City.
Sujuan GaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis.
Sophia WangDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis.
Ben L ZarzaurDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison.
Omar RahmanDepartment of Medicine, Indiana University School of Medicine, Indianapolis.
Ahmed EltarrasDepartment of Medicine, Indiana University School of Medicine, Indianapolis.
Hadi QureshiIndiana University Center for Aging Research, Indianapolis.
Malaz A BoustaniDepartment of Medicine, Indiana University School of Medicine, Indianapolis.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USRegenstrief Institute · USUniversity of Missouri–Kansas City · USUniversity of Wisconsin–Madison · US

Funding

Mobile Critical Care Recovery Program (m-CCRP) for Acute Respiratory Failure (ARF) SurvivorsR01HL131730 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KHAN, BABAR A · 2017 to 2021
$3.2M
Reactive Oxygen Species in Respiratory Failure, Delirium, and Post-ICU Cognitive ImpairmentK76AG074925 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Sikandar Hayat Khan · 2022 to 2026
$1.1M
NHLBI NIH HHS R01 HL131730
6 · The paper itself

Abstract

Importance: Over 50% of Acute Respiratory Failure (ARF) survivors experience cognitive, physical, and psychological impairments that negatively impact their quality of life (QOL). Objective: To evaluate the efficacy of a post-intensive care unit (ICU) program, the Mobile Critical Care Recovery Program (m-CCRP) consisting of a nurse care coordinator supported by an interdisciplinary team, in improving the QOL of ARF survivors. Design, Setting, and Participants: This randomized clinical trial with concealed outcome assessments among ARF survivors was conducted from March 1, 2017, to April 30, 2022, with a 12-month follow-up. Patients were admitted to the ICU services of 4 Indiana hospitals (1 community, 1 county, 2 academic), affiliated with the Indiana University School of Medicine. Intervention: A 12-month nurse-led collaborative care intervention (m-CCRP) supported by an interdisciplinary group of clinicians (2 intensivists, 1 geriatrician, 1 ICU nurse, and 1 neuropsychologist) was compared with a telephone-based control. The intervention comprised longitudinal symptom monitoring coupled with nurse-delivered care protocols targeting cognition, physical function, personal care, mobility, sleep disturbances, pain, depression, anxiety, agitation or aggression, delusions or hallucinations, stress and physical health, legal and financial needs, and medication adherence. Main Outcomes and Measures: The primary outcome was QOL as measured by the 36-item Medical Outcomes Study Short Form Health Survey (SF-36) physical component summary (PCS) and mental component summary (MCS), with scores on each component ranging from 0-100, and higher scores indicating better health status. Results: In an intention-to-treat analysis among 466 ARF survivors (mean [SD] age, 56.1 [14.4] years; 250 [53.6%] female; 233 assigned to each group), the m-CCRP intervention for 12 months did not significantly improve the QOL compared with the control group (estimated difference in change from baseline between m-CCRP and control group: 1.61 [95% CI, -1.06 to 4.29] for SF-36 PCS; -2.50 [95% CI, -5.29 to 0.30] for SF-36 MCS. Compared with the control group, the rates of hospitalization were higher in the m-CCRP group (117 [50.2%] vs 95 [40.8%]; P = .04), whereas the 12-month mortality rates were not statistically significantly lower (24 [10.3%] vs 38 [16.3%]; P = .05). Conclusions and Relevance: Findings from this randomized clinical trial indicated that a nurse-led 12-month comprehensive interdisciplinary care intervention did not significantly improve the QOL of ARF survivors after ICU hospitalization. These results suggest that further research is needed to identify specific patient groups who could benefit from tailored post-ICU interventions. Trial Registration: ClinicalTrials.gov Identifier: NCT03053245.

Indexed as

Quality of LifeRespiratory InsufficiencyAggressionCritical CareFemaleHumansIntensive Care UnitsMaleMiddle Aged

Identifiers

PMID38289602
PMCPMC10828910
OpenAlexW4391346559

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.