Evidence map›Paper›PMID 38289501›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Mallory-Denk bodies and hepatocellular senescence: a causal relationship?

Helmut Denk, Peter M Abuja, Kurt Zatloukal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Autophagy in MASLD: A Metabolic and Precision Medicine Perspective.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Helmut DenkDiagnostic and Research Institute of Pathology, Diagnostic & Research Center of Molecular Biomedicine, Medical University of Graz, Neue Stiftingtalstrasse 6, A-8010, Graz, Austria. helmut.denk@medunigraz.at.ORCID http://orcid.org/0000-0001-6959-0828
Peter M AbujaDiagnostic and Research Institute of Pathology, Diagnostic & Research Center of Molecular Biomedicine, Medical University of Graz, Neue Stiftingtalstrasse 6, A-8010, Graz, Austria.
Kurt ZatloukalDiagnostic and Research Institute of Pathology, Diagnostic & Research Center of Molecular Biomedicine, Medical University of Graz, Neue Stiftingtalstrasse 6, A-8010, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mallory-Denk bodies (MDBs) are hepatocellular cytoplasmic inclusions, which occur in certain chronic liver diseases, such as alcohol-related (ASH) and metabolic dysfunction-associated (MASH) steatohepatitis, copper toxicosis, some drug-induced liver disorders, chronic cholangiopathies, and liver tumors. Our study focused on the expression of the senescence markers p21

Indexed as

Cellular SenescenceCyclin-Dependent Kinase Inhibitor p16HepatocytesMallory BodiesBiomarkersCarcinoma, HepatocellularCyclin-Dependent Kinase Inhibitor p21HumansLiverLiver DiseasesLiver NeoplasmsBiomarkersCDKN1A protein, humanCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Cellular senescenceChronic cholangiopathyKeratinsMallory-Denk bodiesSteatohepatitis

Identifiers

PMID38289501
PMCPMC11063002

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.