ReviewActa neurochirurgica2024
Malignant transformation of vestibular schwannoma following radiosurgery-a case report and review of the literature.
Review in Acta neurochirurgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recurrence of a Benign Tumor: The Challenge of a Knee Intra-articular Schwannoma - A Case Report.Journal of orthopaedic case reports · 2026Article
- Clinical Diagnosis and Treatment in Patients with Schwannoma at a Single Institute.Diagnostics (Basel, Switzerland) · 2026Article
- Rapid Malignant Transformation of a Biopsy Proven Sporadic Soft Tissue Schwannoma to Spindle Cell MPNST WithInternational journal of surgical pathology · 2025Article
- Incidence of rare malignant transformation in vestibular schwannomas treated with stereotactic radiosurgery: a single-institution analysis of 1,061 cases.Journal of neuro-oncology · 2025Article
- Clinical benefits of central pancreatectomy for a patient with pancreatic schwannoma and diabetes.World journal of surgical oncology · 2025Article
- Malignant transformation of vestibular schwannoma 29 years after Gamma Knife radiosurgery: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Malignant transformation of vestibular schwannoma after radiation therapy.Radiology case reports · 2024Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant transformation of vestibular schwannoma (VS) post-radiosurgery is an extremely rare but life-threatening complication. We present a patient who underwent two surgeries for a benign VS and received Gamma Knife radiosurgery for residual tumour. Five and a half years post-radiosurgery, the patient was reoperated for symptomatic recurrence of the tumour. Histopathology confirmed the diagnosis of a high-grade spindle cell sarcoma. Although near-total resection was uneventful, the patient deteriorated rapidly, and comfort care was chosen. This report is the 13th documented case of histopathologically confirmed malignant transformation of a benign VS that strictly meets the modified Cahan's criteria, suggesting the direct link to radiosurgery-induced malignancy.
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Registered trials
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