Evidence map›Paper›PMID 38289467›Full record

ArticleDrug delivery and translational research2024

Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery.

Ilaria Polidori, Dennis To, Gergely Kali, Andreas Bernkop-Schnürch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery and translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilaria PolidoriDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innsbruck, 6020, Austria.
Dennis ToDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innsbruck, 6020, Austria.
Gergely KaliDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innsbruck, 6020, Austria.
Andreas Bernkop-SchnürchDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, University of Innsbruck, Innsbruck, 6020, Austria. Andreas.Bernkop@uibk.ac.at.ORCID 0000-0003-4187-8277

Funding

EUREGIO IPN178 - CUP H35F21001410003
6 · The paper itself

Abstract

The aim of this study was to design surfactants based on histidine (His) for hydrophobic ion-pairing and evaluate their safety and efficacy. Lauryl, palmitoyl and oleyl alcohol, as well as 2-hexyl-1-decanol were converted into surfactants with histidine as head-group via esterification. The synthesized His-surfactants were characterized regarding pK

Indexed as

Cell SurvivalHistidineHydrophobic and Hydrophilic InteractionsSurface-Active AgentsCaco-2 CellsCationsDNADrug Delivery SystemsHeparinHumansMicellesPlasmidsCationsDNAHeparinHistidineMicellesSurface-Active AgentsBiodegradable surfactantsDNA deliveryHistidineHydrophobic ion-pairingIonizable cationic lipidsLipid-based formulations

Identifiers

PMID38289467
PMCPMC11291603

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.