Evidence map›Paper›PMID 38289383›Full record

ReviewApplied microbiology and biotechnology2024

Bacillus and Streptomyces spp. as hosts for production of industrially relevant enzymes.

Sandra Vojnovic, Ivana Aleksic, Tatjana Ilic-Tomic, Milena Stevanovic, Jasmina Nikodinovic-Runic

Open access · goldAbstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Synthetic and systems biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Biogenic Quorum-Sensing Amides fromMolecules (Basel, Switzerland) · 2026
    Article
  9. Article
  10. Article
  11. Biotech (Basel (Switzerland)) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Genomic Characterization ofMicroorganisms · 2024
    Article
  18. Article
  19. Article
  20. Partitioning purification, biochemical characterization, and milk coagulation efficiency of protease from a newly Streptomyces sp. isolate.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Sandra VojnovicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042, Belgrade 152, Serbia. sandravojnovic@imgge.bg.ac.rs.ORCID http://orcid.org/0000-0002-5083-4287
Ivana AleksicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042, Belgrade 152, Serbia.ORCID http://orcid.org/0000-0001-5635-0024
Tatjana Ilic-TomicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042, Belgrade 152, Serbia.ORCID http://orcid.org/0000-0001-7198-2855
Milena StevanovicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042, Belgrade 152, Serbia.ORCID http://orcid.org/0000-0002-5590-685X
Jasmina Nikodinovic-RunicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042, Belgrade 152, Serbia. jasmina.nikodinovic@imgge.bg.ac.rs.ORCID http://orcid.org/0000-0002-2553-977X
University of Belgrade · RS

Funding

Horizon 2020 870292Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-47/2023-01/ 200042
6 · The paper itself

Abstract

The application of enzymes is expanding across diverse industries due to their nontoxic and biodegradable characteristics. Another advantage is their cost-effectiveness, reflected in reduced processing time, water, and energy consumption. Although Gram-positive bacteria, Bacillus, and Streptomyces spp. are successfully used for production of industrially relevant enzymes, they still lag far behind Escherichia coli as hosts for recombinant protein production. Generally, proteins secreted by Bacillus and Streptomyces hosts are released into the culture medium; their native conformation is preserved and easier recovery process enabled. Given the resilience of both hosts in harsh environmental conditions and their spore-forming capability, a deeper understanding and broader use of Bacillus and Streptomyces as expression hosts could significantly enhance the robustness of industrial bioprocesses. This mini-review aims to compare two expression hosts, emphasizing their specific advantages in industrial surroundings such are chemical, detergent, textile, food, animal feed, leather, and paper industries. The homologous sources, heterologous hosts, and molecular tools used for the production of recombinant proteins in these hosts are discussed. The potential to use both hosts as biocatalysts is also evaluated. Undoubtedly, Bacillus and Streptomyces spp. as production hosts possess the potential to take on a more substantial role, providing superior (bio-based) process robustness and flexibility. KEY POINTS: • Bacillus and Streptomyces spp. as robust hosts for enzyme production. • Industrially relevant enzyme groups for production in alternative hosts highlighted. • Molecular biology techniques are enabling easier utilization of both hosts.

Indexed as

BacillusAnimal FeedAnimalsBiological TransportCulture MediaEscherichia coliCulture MediaBacillusBiocatalysisEnzymeExpressionStreptomyces

Identifiers

PMID38289383
PMCPMC10827964
OpenAlexW4391360095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.