Evidence map›Paper›PMID 38289201›Full record

ReviewJBRA assisted reproduction2024

Sperm DNA Fragmentation: causes, evaluation and management in male infertility.

Syed Waseem Andrabi, Anam Ara, Ankur Saharan, Mir Jaffar, Nivita Gugnani, Sandro C Esteves

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JBRA assisted reproduction, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  15. MicroRNA dysregulation in male infertility: Insights into mechanisms, biomarkers, and therapeutic strategies- review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Syed Waseem AndrabiNova Southend Fertility and IVF centre New Delhi Nova Southend Fertility and IVF centre, New Delhi.
Anam AraUniversity of Manitoba Winnipeg Canada University of Manitoba, Winnipeg, Canada.
Ankur SaharanAmity University Lucknow India Amity University, Lucknow, India.
Mir JaffarValley Fertility Centre Srinagar India Valley Fertility Centre, Srinagar, India.
Nivita GugnaniRidge IVF Centre New Delhi Ridge IVF Centre, New Delhi.
Sandro C EstevesANDROFERT, Andrology and Human Reproduction Clinic, Campinas, SP, Brazil.
Bloom Fertility Centre · INUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility is a great matter of concern as out of 15% of infertile couples in the reproductive age, about 40% are contributed by male factors alone. For DNA condensation during spermatogenesis, constrained DNA nicking is required, which if increased beyond certain level results in infertility in men. High sperm DNA Fragmentation (SDF) majorly contributes to male infertility and its association with regards to poor natural conception and assisted reproductive technology (ART) outcomes is equivocal. Apoptosis, protamination failure and the excess of reactive oxygen species (ROS) are considered to be the main causes of SDF. It's testing came into existence because of the limitations of the conventional methods in explaining infertility in normozoospermic infertile individuals. Over the past 25 years, SDF's several testing strategies have been proposed to diagnose the aetiology of infertility. Various treatments combined with sperm selection techniques are being used alone or in combination to reduce DNA fragmentation index (DFI) and obtain spermatozoa with high quality chromatin for assisted reproduction. This review summarises SDF's main causes, its impact on fertility and clinical outcomes in assisted reproduction, the need to perform test, testing procedures, and the treatment strategies.

Indexed as

DNA FragmentationInfertility, MaleSpermatozoaHumansMaleReproductive Techniques, Assistedassisted reproductive techniquesDNA fragmentationmale infertilityreproductive biologysperm

Identifiers

PMID38289201
PMCPMC11152411
OpenAlexW4391364756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.