Evidence map›Paper›PMID 38289047›Full record

ArticleMicrobiology spectrum2024

Exploring nasopharyngeal microbiota profile in children affected by SARS-CoV-2 infection.

L Romani, F Del Chierico, S Pane, M V Ristori, I Pirona, V Guarrasi, N Cotugno, S Bernardi, L Lancella, C F Perno and 6 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Characteristics of lower respiratory microbiota in children's refractoryFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

L Romani *Infectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
F Del Chierico *Research Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID 0000-0002-4204-4736
S PaneUnit of Microbiomics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
M V RistoriResearch Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
I PironaGenomeUp SRL, Viale Pasteur, Rome, Italy.
V GuarrasiGenomeUp SRL, Viale Pasteur, Rome, Italy.
N CotugnoResearch Unit of Congenital and Perinatal Infections, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
S BernardiInfectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
L LancellaInfectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
C F PernoUnit of Microbiology and Diagnostic Immunology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID 0000-0002-0825-5388
P RossiDepartment of Systems Medicine, University of Rome ''Tor Vergata'', Rome, Italy.
A VillaniPediatric Emergency Department and General Pediatrics, Bambino Gesù Children's Hospital Bambino Gesù, IRCCS, Rome, Italy.
A CampanaDepartment of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
P PalmaResearch Unit of Congenital and Perinatal Infections, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
L PutignaniUnit of Microbiomics and Research Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID 0000-0003-0134-2830
CACTUS Study Team
Bambino Gesù Children's Hospital · ITUniversity of Rome Tor Vergata · IT

Funding

Italian Ministry of Health Current Research fundsMinistero della Salute (Italy Ministry of Health)The BioArte Limited 202003_Bioarte_Putignani
6 · The paper itself

Abstract

The relationship between COVID-19 and nasopharyngeal (NP) microbiota has been investigated mainly in the adult population. We explored the NP profile of children affected by COVID-19, compared to healthy controls (CTRLs). NP swabs of children with COVID-19, collected between March and September 2020, were investigated at the admission ( IMPORTANCE: Since the beginning of pandemic, we know that children are less susceptible to severe COVID-19 disease. A potential role of the nasopharyngeal (NP) microbiota has been hypothesized but to date, most of the studies have been focused on adults. We studied the NP microbiota modifications in children affected by SARS-CoV-2 infection showing a specific NP microbiome profile, mainly composed by pathobionts and almost missing protective anaerobic commensals. Moreover, in our study, specific microbial signatures appear since the first days of infection independently from SARS-CoV-2 viral load.

Indexed as

COVID-19MicrobiotaAdultChildHumansNasopharynxRNA, Ribosomal, 16SSARS-CoV-2StreptococcusRNA, Ribosomal, 16SchildrenCOVID-19nasopharyngeal microbiotarespiratory tractSARS-CoV-2

Identifiers

PMID38289047
PMCPMC10913489
OpenAlexW4391349264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.