Evidence map›Paper›PMID 38289044›Full record

ArticleAntimicrobial agents and chemotherapy2024

Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant

Magdalena Zalacain, Pauline Achard, Agustina Llanos, Ian Morrissey, Stephen Hawser, Kirsty Holden, Eleanor Toomey, David Davies, Simon Leiris, Carole Sable and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Resistance ofPathogens (Basel, Switzerland) · 2025
    Pooled it
  3. Review
  4. Membrane-Focused Strategies AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  5. Disarming carbapenemase-producingAntimicrobial agents and chemotherapy · 2026
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Magdalena ZalacainAntabio SAS, Labège, France.ORCID 0000-0002-5987-0188
Pauline AchardAntabio SAS, Labège, France.
Agustina LlanosAntabio SAS, Labège, France.
Ian MorrisseyIHMA Europe, Monthey/VS, Switzerland.
Stephen HawserIHMA Europe, Monthey/VS, Switzerland.
Kirsty HoldenEvotec, Macclesfield, United Kingdom.
Eleanor ToomeyEvotec, Macclesfield, United Kingdom.
David DaviesAntabio SAS, Labège, France.
Simon LeirisAntabio SAS, Labège, France.
Carole SableAntabio SAS, Labège, France.
Adeline LedouxAntabio SAS, Labège, France.
Justine BousquetAntabio SAS, Labège, France.
Jérôme CastandetAntabio SAS, Labège, France.
Clarisse LozanoAntabio SAS, Labège, France.
Martin EverettAntabio SAS, Labège, France.
Marc LemonnierAntabio SAS, Labège, France.
Evotec (United Kingdom) · GB

Funding

Contrat Innovation, Region Occitanie grant 20006316
6 · The paper itself

Abstract

ANT3310 is a novel broad-spectrum diazabicyclooctane serine β-lactamase inhibitor being developed in combination with meropenem (MEM) for the treatment of serious infections in hospitalized patients where carbapenem-resistant Gram-negative pathogens are expected. In this study, we evaluated the

Indexed as

Acinetobacter baumanniibeta-Lactamase InhibitorsAnimalsAnti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamasesCarbapenemsDrug CombinationsHumansLactamsMeropenemMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamasesCarbapenemsDrug CombinationsLactamsMeropenemA. baumanniiANT3310carbapenem-resistancemeropenemβ-lactamase inhibitor

Identifiers

PMID38289044
PMCPMC10916402
OpenAlexW4391349251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.