Evidence map›Paper›PMID 38289021›Full record

ArticleACS chemical biology2024

Characterization of Dichloroisoeverninic Acid Biosynthesis and Chemoenzymatic Synthesis of New Orthosomycins.

Audrey E Yñigez-Gutierrez, Jennifer E Wurm, Jordan T Froese, Nicholas E Rosenthal, Brian O Bachmann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Audrey E Yñigez-GutierrezDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Jennifer E WurmDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0566-3845
Jordan T FroeseDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Nicholas E RosenthalDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Brian O BachmannDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0001-5815-1176
Vanderbilt University · US

Funding

Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Biosynthesis and Synthetic Biology of Antibiotic OligosaccharidesR01AI140400 · NIAID · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, IVERSON, T M · 2019 to 2022
$2.0M
Vanderbilt Chemical Biology Interface Training ProgramT32GM149371 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2023 to 2026
$1.7M
NIAID NIH HHS R01 AI140400NIGMS NIH HHS T32 GM065086NIGMS NIH HHS T32 GM149371
6 · The paper itself

Abstract

The orthosomycins are highly modified oligosaccharide natural products with a broad spectrum and potent antimicrobial activities. These include everninomicins and avilamycins, which inhibit protein translation by binding a unique site on the bacterial ribosome. Notably, ribosomal bound structures reveal a network of interactions between the 50S subunit and dichloroisoeverninic acid (DCIE), the aromatic A

Indexed as

Anti-Bacterial AgentsParabensBiosynthetic PathwaysOligosaccharidesAnti-Bacterial Agentsdichloroisoeverninic acidOligosaccharidesParabens

Identifiers

PMID38289021
PMCPMC12281588
OpenAlexW4391348978

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.