Evidence map›Paper›PMID 38288820›Full record

ArticleProtein and peptide letters2024

P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats.

Tianxia Li, Yuexin Jia, Junxian Fu, Zhuo Fu, Zhidong Qiao, Xiaoyang Liu, Ting Lv, Rong Tang, Guanglu Yang

Abstract read
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In one paragraph

Article in Protein and peptide letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tianxia LiDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Yuexin JiaDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Junxian FuDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Zhuo FuDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Zhidong QiaoDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Xiaoyang LiuDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Ting LvDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Rong TangDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Guanglu YangDepartment of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Inner Mongolia Medical University · CN

Funding

Inner Mongolia Autonomous Region Neurological Disease Clinical Medicine Research Center MYYXT201903Inner Mongolia Science and Technology Department 2020GG0139Major Project of Inner Mongolia Medical University kjbw2012005Major Scientific Research Project of Affiliated Hospital of Inner Mongolia Medical University NTFYZD022National Natural Science Foundation of China 8226050455Natural Science Foundation of Inner Mongolia Autonomous Region 2015MS08103Youth Science and Technology Talents Program-Class A NJYT-17-A1
6 · The paper itself

Abstract

objectivesIn this study, we employed an

methods(1) Within the first 24 hours after birth, the bilateral cortex was extracted from newborn Wistar rats and primary cortical neurons were cultured and identified. (2) The changes in the mRNA and protein expressions of GAP-43 induced by p53 in rat primary cortical neurons cultured in vitro were identified utilizing real-time polymerase chain reaction and western blot techniques.

results(1) Lentiviral transfection of p53 within primary cortical neurons of rats elicited elevated levels of both mRNA and protein expressions of GAP-43, consequently culminating in a noteworthy augmentation of p53 expression. (2) The introduction of a p53 inhibitor in rat primary cortical neurons resulted in a reduction in both mRNA and protein expressions of GAP-43.

conclusionWithin primary rat cortical neurons, p53 has the potential to prompt an augmentation in both the transcriptional and protein expression levels of the GAP-43 protein.

Indexed as

Cerebral CortexGAP-43 ProteinNeuronsRats, WistarTumor Suppressor Protein p53Up-RegulationAnimalsCells, CulturedRatsRNA, MessengerGAP-43 ProteinRNA, MessengerTp53 protein, ratTumor Suppressor Protein p53Cortical neuronGAP-43p53primary cell cultureprotein expression.western blot techniques

Identifiers

PMID38288820
OpenAlexW4391310663

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.