Evidence map›Paper›PMID 38288793›Full record

ReviewCurrent pharmaceutical biotechnology2024

Recent Advances in Pharmaceutical Design: Unleashing the Potential of Novel Therapeutics.

Ram Narayan Prajapati, Bharat Bhushan, Kuldeep Singh, Himansu Chopra, Shivendra Kumar, Mehak Agrawal, Devender Pathak, Dilip Kumar Chanchal, Laxmikant

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ram Narayan PrajapatiDepartment of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi-284128 (UP) India.ORCID 0000-0002-7233-6051
Bharat BhushanDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura Uttar Pradesh, India.ORCID 0000-0002-0691-8408
Kuldeep SinghDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh India.ORCID 0000-0001-8772-8157
Himansu ChopraDepartment of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh, India.ORCID 0000-0002-4962-8195
Shivendra KumarDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh India.ORCID 0000-0002-2287-6981
Mehak AgrawalDepartment of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh, India.ORCID 0000-0002-2798-8536
Devender PathakDepartment of Chemistry, Rajiv Academy for Pharmacy, Mathura Uttar Pradesh, India.ORCID 0000-0002-1862-1484
Dilip Kumar ChanchalDepartment of Pharmacognosy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India.ORCID 0000-0002-8937-3748
LaxmikantDepartment of Chemistry, Agra Public Pharmacy College, Artoni Agra, Uttar Pradesh, India.ORCID 0000-0002-6927-4582
Rajiv Gandhi University of Health Sciences · INBundelkhand University · INDr. Bhim Rao Ambedkar University · INGLA University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmaceutical design has made significant advancements in recent years, leading to the development of novel therapeutics with unprecedented efficacy and safety profiles. This review highlights the potential of these innovations to revolutionize healthcare and improve patient outcomes. The application of cutting-edge technologies like artificial intelligence, machine learning, and data mining in drug discovery and design has made it easier to find potential drug candidates. Combining big data and omics has led to the discovery of new therapeutic targets and personalized medicine strategies. Nanoparticles, liposomes, and microneedles are examples of advanced drug delivery systems that allow precise control over drug release, better bioavailability, and targeted delivery to specific tissues or cells. This improves the effectiveness of the treatment while reducing side effects. Stimuli-responsive materials and smart drug delivery systems enable drugs to be released on demand when specific internal or external signals are sent. Biologics and gene therapies are promising approaches in pharmaceutical design, offering high specificity and potency for treating various diseases like cancer, autoimmune disorders, and infectious diseases. Gene therapies hold tremendous potential for correcting genetic abnormalities, with recent breakthroughs demonstrating successful outcomes in inherited disorders and certain types of cancer. Advancements in nanotechnology and nanomedicine have paved the way for innovative diagnostic tools and therapeutics, such as nanoparticle-based imaging agents, targeted drug delivery systems, gene editing technologies, and regenerative medicine strategies. Finally, the review emphasizes the importance of regulatory considerations, ethical challenges, and future directions in pharmaceutical design. Regulatory agencies are adapting to the rapid advancements in the field, ensuring the safety and efficacy of novel therapeutics while fostering innovation. Ethical considerations regarding the use of emerging technologies, patient privacy, and access to advanced therapies also require careful attention.

Indexed as

Drug Delivery SystemsDrug DesignAnimalsArtificial IntelligenceGenetic TherapyHumansNanomedicineNanoparticlesclinical trials.drug delivery systemsdrug discoverygenomicsnanotechnologynatural productsPharmaceutical designtherapeutic potentialtraditional medicine

Identifiers

PMID38288793
OpenAlexW4391310669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.