Evidence map›Paper›PMID 38288459›Full record

ArticleCase reports in oncology

HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man.

Nikolay Grachev, Gavriil Rabaev, Ashot Avdalyan, Igor Znamenskiy, Dmitry Mosin, Dmitry Ustyuzhanin, Gennady Rabaev, Martin Lužbeták

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Nikolay GrachevDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russian Federation, Moscow, Russia.
Gavriil RabaevDepartment of Pediatric Oncology and Surgery, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russian Federation, Moscow, Russia.
Ashot AvdalyanDepartment of Pathology of the Moscow Multidisciplinary Clinical Center «Kommunarka» of Moscow Healthcare Department, Moscow, Russia.
Igor ZnamenskiyDepartment of Radionuclide Diagnostic Methods of the Federal State Budgetary Research Institution «Russian Research Center of Surgery Named after Academician B.V. Petrovsky», Department of Radiation Diagnostics and Therapy of the Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.
Dmitry MosinFederal State Budgetary Research Institution «Russian Research Center of Surgery Named after Academician B.V. Petrovsky», Department of the Rentgenoradiologi, Pirogov Russian National Research Medical University, Moscow, Russia.
Dmitry UstyuzhaninDepartment of Tomography, Evgeny Chazov National Medical Research Center of Cardiology, Moscow, Russia.
Gennady RabaevDepartment of Oncology, LLC Onco Genotest, Moscow, Russia.
Martin LužbetákDepartment of Preventive Medicine (Dresden International University, Dresden), NextGen Oncology Group, Düsseldorf, Germany.
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RUDresden International University · DEMinistry of Health of the Russian Federation · RUNational Medical Research Center of Cardiology · RURussian Scientific Center of Surgery · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lacrimal sac squamous cell carcinoma (SCC) is a rare tumor. Only 241 cases of lacrimal sac SCC have been reported in the literature. However, the detailed molecular profile of this tumor is unknown. Case Presentation: Fifty-seven-year-old Caucasian male presented with a 6-month history of epiphora. Multimodal examination revealed a unilateral lacrimal sac SCC T4aN0M0. The patient underwent primary surgery with subsequent chemoradiotherapy. The patient was alive 18 months after the end of the treatment, with no signs of local or distant relapse. Complex molecular profiling revealed the FGFR p.G388R variant, HER2 amplification, and progression phenotype. Conclusion: Here, we describe a clinical case of a male patient with lacrimal sac SCC with a careful description of the disease history, treatment, and molecular-genetic patterns of the tumor. This is the first report of HER2-positive lacrimal sac SCC.

Indexed as

Epithelial lacrimal sac tumorsHER2 amplificationMolecular profileSquamous cell carcinoma

Identifiers

PMID38288459
PMCPMC10824523
OpenAlexW4391301963

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.