Evidence map›Paper›PMID 38288336›Full record

ReviewFrontiers in molecular biosciences2023

Recent advances in infectious disease research using cryo-electron tomography.

Daniel Asarnow, Vada A Becker, Daija Bobe, Charlie Dubbledam, Jake D Johnston, Mykhailo Kopylov, Nathalie R Lavoie, Qiuye Li, Jacob M Mattingly, Joshua H Mendez and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniel Asarnow *Department of Biochemistry, University of Washington, Seattle, WA, United States.
Vada A Becker *Department of Medicinal Chemistry, University of Washington, Seattle, WA, United States.
Daija Bobe *Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
Charlie Dubbledam *Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
Jake D Johnston *Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
Mykhailo Kopylov *Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
Nathalie R Lavoie *Department of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, MA, United States.
Qiuye Li *Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Jacob M Mattingly *Department of Chemistry, College of Arts and Sciences, Emory University, Atlanta, GA, United States.
Joshua H Mendez *Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
Mohammadreza Paraan *Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.
Jack Turner *European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
Viraj Upadhye *Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Richard M Walsh *Harvard Cryo-Electron Microscopy Center for Structural Biology and Harvard Medical School, Boston, MA, United States.
Meghna GuptaDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, United States.
Edward T EngSimons Electron Microscopy Center, New York Structural Biology Center, New York, NY, United States.

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Peroxisomal fatty acid metabolism in genetic and age-related disordersK99AG070271 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUPTA, MEGHNA · 2022 to 2023
$250k
NIA NIH HHS K99 AG070271NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this structural biology technique to help discover mechanisms of infection in native environments and guiding in the right direction for future drug discovery.

Indexed as

bacteriacryo-EMcryo-EThost-pathogen interactioninfectious diseasespathogenviruses

Identifiers

PMID38288336
PMCPMC10822977

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.