Evidence map›Paper›PMID 38288300›Full record

ArticleFrontiers in medicine2023

OCT angiography indices and the choroidal vascularity index in wild-type transthyretin (TTR) amyloidosis (ATTRwt).

Michele Rinaldi, Fausto Tranfa, Flavia Chiosi, Giuseppe Campagna, Maddalena De Bernardo, Marco Gioia, Francesco Natale, Martina Caiazza, Francesca Dongiglio, Federica Verrillo and 3 more

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Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Michele Rinaldi *Department of Ophthalmology, Università degli studi della Campania "Luigi Vanvitelli", Naples, Italy.
Fausto Tranfa *Department of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of Naples, Naples, Italy.
Flavia ChiosiDepartment of Ophthalmology, Azienda Ospedaliera dei Colli, Monaldi Hospital, Naples, Italy.
Giuseppe CampagnaDepartment of Medical-Surgical Sciences and Translational Medicine, University of Rome "Sapienza", Rome, Italy.
Maddalena De BernardoEye Unit, Department of Medicine Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Marco GioiaEye Unit, Department of Medicine Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Francesco NataleDepartment of Cardiothoracic Sciences, Università degli studi della Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Martina CaiazzaInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Francesca DongiglioInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Federica VerrilloInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Giuseppe PalmieroInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Giuseppe LimongelliInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Monaldi Hospital, Naples, Italy.
Ciro CostagliolaDepartment of Neuroscience, Reproductive and Dentistry Sciences, Federico II University of Naples, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Retinal angiopathy represents a well-known ocular manifestation of hereditary transthyretin amyloidosis (ATTRv). Until recently, there have been no reports on retinal changes in ATTRwt. In this retrospective observational clinical study, we aimed to determine whether vessel density (VD) indices and the choroidal vascularity index (CVI) could offer insights into retinal and choroidal vascular changes among patients affected by ATTRwt. Methods: Eighteen patients with a confirmed diagnosis of ATTRwt underwent structural optical coherence tomography (OCT) and OCT angiography (OCTA). We established a control group consisting of 16 healthy subjects for statistical comparisons. The 3D OCT and OCTA datasets were analyzed to assess retinal and choroidal thickness and VD. For measuring CVI, we obtained measurements for the total choroid area (TCA), luminal area (LA), and stromal area (SA). Results: The mean VD exhibited a statistically significant reduction in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) among the ATTRwt group in comparison to the control group ( Conclusion: The indices from OCTA and CVI have the potential to serve as non-invasive biomarkers for the quantitative evaluation of retinal and choroidal vascular involvement in patients with ATTRwt.

Indexed as

choroidal vascularity index (CVI)OCT angiography (OCTA)retinal and choroidal microangiopathyretinal vessel densitywild-type (ATTRwt) transthyretin amyloidosis

Identifiers

PMID38288300
PMCPMC10823855

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