ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Midlife sensory and motor functions improve long-term predictions of cognitive decline and incidence of cognitive impairment.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 3 citations in OpenAlex.
- A sensorimotor function construct to assess mild cognitive impairment risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Trajectories of cognitive decline before and after new-onset dual sensory impairment: findings from two longitudinal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Midlife sensory and motor measures among best predictors in parsimonious models of long-term cognitive decline and incidence of cognitive impairment in aging adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Average performance and performance variability on a brief functional fine motor test reflect distinct behavioral constructs in aging.Frontiers in aging neuroscience · 2026Article
- Sensory changes in preclinical, prodromal, and clinical Alzheimer's disease and related dementias.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Midlife sensory and motor functions improve long-term predictions of cognitive decline and incidence of cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Driving into diagnosis: Leveraging high-resolution telematics and sensorimotor profiling to identify preclinical Alzheimer's disease.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionWe aimed to assess whether midlife sensory and motor functions improve risk prediction of 10-year cognitive decline and impairment when added to risk prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia Score (CAIDE) and Framingham Risk Score (FRS).
methodsLongitudinal data of
resultsAdding sensory and motor measures to CAIDE-only and FRS-only models significantly improved areas under the curve for cognitive decline and impairment models. DISCUSSION: Including midlife sensory and motor function improved risk predictions of long-term cognitive decline and impairment in middle-aged to older adults. Sensory and motor assessments could contribute to cost-effective and non-invasive screening tools that identify high-risk individuals earlier to target intervention and prevention strategies. Highlights: Sensory and motor measures improve risk prediction models of cognitive decline.Sensory and motor measures improve risk prediction models of cognitive impairment.Prediction improvements were strongest in midlife (adults < 55 years of age).Sensory and motor changes may help identify high-risk individuals early.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.