Evidence map›Paper›PMID 38288152›Full record

ReviewRSC advances2024

Exploring the untapped pharmacological potential of imidazopyridazines.

M Shaheer Malik, Hossa F Alshareef, Khalid A Alfaidi, Hissana Ather, Zainularifeen Abduljaleel, Essam M Hussein, Ziad Moussa, Saleh A Ahmed

Abstract readReview
In one paragraph

Review in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M Shaheer MalikDepartment of Chemistry, Faculty of Science, Umm Al-Qura University Makkah 21955 Saudi Arabia.ORCID https://orcid.org/0000-0002-5916-9041
Hossa F AlshareefDepartment of Chemistry, Faculty of Science, Umm Al-Qura University Makkah 21955 Saudi Arabia.
Khalid A AlfaidiDepartment of Chemistry, Faculty of Science, Umm Al-Qura University Makkah 21955 Saudi Arabia.
Hissana AtherScience and Technology Unit, Umm Al-Qura University Makkah 21955 Saudi Arabia.
Zainularifeen AbduljaleelDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University (KKU) Abha 62529 Saudi Arabia.
Essam M HusseinDepartment of Chemistry, Faculty of Science, Umm Al-Qura University Makkah 21955 Saudi Arabia.ORCID https://orcid.org/0000-0003-4778-540X
Ziad MoussaDepartment of Chemistry, College of Science, United Arab Emirates University P.O. Box 15551 Al Ain United Arab Emirates msmalik@uqu.edu.sa saahmed@uqu.edu.sa.ORCID https://orcid.org/0000-0002-3365-0451
Saleh A AhmedDepartment of Chemistry, Faculty of Science, Umm Al-Qura University Makkah 21955 Saudi Arabia.ORCID https://orcid.org/0000-0002-2364-0380

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

Identifiers

PMID38288152
PMCPMC10823362

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.