ArticleFrontiers in microbiology2023
Causal relationship between gut microflora and dementia: a Mendelian randomization study.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Gut microbiome intervention in gut-brain axis and effects on vascular dementia with prospects on non-pharmacological intervention.Biochemistry and biophysics reports · 2026Review
- Modulating the Gut-Microbiota-Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors.CNS neuroscience & therapeutics · 2026Review
- Modifiable and clinically actionable exposures for vascular dementia: a structured evidence synthesis of Mendelian randomization studies.Journal of neurology · 2026Review
- Causal Relationship Between Gut Microbiota and Female Infertility: A Bidirectional Mendelian Randomization Analysis.JBRA assisted reproduction · 2026Article
- Polyunsaturated fatty acids in biotechnology and health: Sources, Synthesis, Applications, and market trends.Archives of microbiology · 2026Review
- Brain-gut communication and potential applications of microecological treatments in stroke.Frontiers in neuroscience · 2026Review
- Identifying the mediating role of immune cells on the relationship between plasma lipidomes and PCOS: a two-step Mendelian randomization analysis.Journal of ovarian research · 2025Article
- Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice.Toxicology · 2025Article
- Association between sulfur microbial diet and the risk of dementia: a large-scale prospective cohort study.Nutrition journal · 2025Article
- Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis.Medicine · 2025Article
- Oral Administration ofAntioxidants (Basel, Switzerland) · 2025Article
- Exploring the Interaction Mechanisms of Antibody-Mediated Immune Responses with Gout and Rheumatoid Arthritis Through a Bidirectional Two-Sample Mendelian Randomization Study.Journal of pain research · 2025Article
- Effects of gut microbiota on cognitive impairment in Parkinson's disease: a comprehensive Mendelian randomization and case-control study.Frontiers in microbiology · 2025Article
- Association of hemorrhoidal disease with dementia risk: a nationwide cohort study.Frontiers in neurology · 2025Article
- Deconstruct the link between gut microbiota and neurological diseases: application of Mendelian randomization analysis.Frontiers in cellular and infection microbiology · 2025Review
- Investigating Causal Associations between the Gut Microbiota and Dementia: A Mendelian Randomization Study.Nutrients · 2024Article
- The causal relationship between gut microbiota and alopecia areata: a Mendelian randomization analysis.Frontiers in microbiology · 2024Article
- Gut microbiota dysbiosis in patients with Alzheimer's disease and correlation with multiple cognitive domains.Frontiers in aging neuroscience · 2024Article
- The causal association between the new gut microbiota and Alzheimer's disease: A Mendelian randomization study.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Numerous pertinent investigations have demonstrated a correlation between gut microflora (GM) and the occurrence of dementia. However, a causal connection between GM and dementia and its subtypes has not yet been clarified. Objective: To explore the causal association between GM and dementia, including its subtypes, a two-sample Mendelian randomization (TSMR) analysis was used. Methods: Our data comes from the Genome-Wide Association Study (GWAS). The principal approach employed for the Mendelian randomization study was the inverse-variance weighted method, supplemented by four methods: MR-Egger, weighted median, simple mode, and weighted mode. This was followed by Cochrane's Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out as sensitivity analysis validation. Results: Twenty-one GMs associated with any dementia, Alzheimer's disease, vascular dementia, Lewy body dementia, Parkinson's disease, and dementia under other disease classifications were derived from the analysis, and 21 passed sensitivity tests. Conclusion: We confirmed the causal relationship between GM and dementia and its subtypes, derived specific flora associated with increased or decreased risk of dementia, and provided new ideas for preventive, diagnostic, and therapeutic interventions for dementia mediated by gut microbiota.
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