Evidence map›Paper›PMID 38287706›Full record

ArticleSocial cognitive and affective neuroscience2024

Identifying cortical structure markers of resilience to adversity in young people using surface-based morphometry.

Harriet Cornwell, Nicola Toschi, Catherine Hamilton-Giachritsis, Marlene Staginnus, Areti Smaragdi, Karen Gonzalez-Madruga, Nuria Mackes, Jack Rogers, Anne Martinelli, Gregor Kohls and 6 more

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In one paragraph

Article in Social cognitive and affective neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Harriet CornwellDepartment of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK.
Nicola ToschiDepartment of Biomedicine and Prevention, University of Rome 'Tor Vergata', Facoltà di Medicina e Chirurgia, Viale Montpellier, Rome 1 - 00133, Italy.
Catherine Hamilton-GiachritsisDepartment of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK.
Marlene StaginnusDepartment of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK.
Areti SmaragdiChild Development Institute, 197 Euclid Ave., Toronto, Ontario, M6J 2J8, Canada.
Karen Gonzalez-MadrugaDepartment of Psychology, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK.
Nuria MackesDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.ORCID 0000-0002-7995-8881
Jack RogersCentre for Human Brain Health, School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Anne MartinelliDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Deutschordenstrasse 50, Frankfurt am Main 60528, Germany.
Gregor KohlsChild Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany.
Nora Maria RaschleDepartment of Child and Adolescent Psychiatry, University of Basel, Psychiatric University Hospital, Wilhelm Klein-Strasse 27, Basel 4002, Switzerland.
Kerstin KonradChild Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany.
Christina StadlerDepartment of Child and Adolescent Psychiatry, University of Basel, Psychiatric University Hospital, Wilhelm Klein-Strasse 27, Basel 4002, Switzerland.
Christine M FreitagDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Deutschordenstrasse 50, Frankfurt am Main 60528, Germany.
Stephane A De BritoCentre for Human Brain Health, School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Graeme FairchildDepartment of Psychology, University of Bath, 10 West, Claverton Down, Bath, Somerset BA2 7AY, UK.ORCID 0000-0001-7814-9938

Funding

Medical Research Council MR/N0137941/1
6 · The paper itself

Abstract

Previous research on the neurobiological bases of resilience in youth has largely used categorical definitions of resilience and voxel-based morphometry methods that assess gray matter volume. However, it is important to consider brain structure more broadly as different cortical properties have distinct developmental trajectories. To address these limitations, we used surface-based morphometry and data-driven, continuous resilience scores to examine associations between resilience and cortical structure. Structural MRI data from 286 youths (Mage = 13.6 years, 51% female) who took part in the European multi-site FemNAT-CD study were pre-processed and analyzed using surface-based morphometry. Continuous resilience scores were derived for each participant based on adversity exposure and levels of psychopathology using the residual regression method. Vertex-wise analyses assessed for correlations between resilience scores and cortical thickness, surface area, gyrification and volume. Resilience scores were positively associated with right lateral occipital surface area and right superior frontal gyrification and negatively correlated with left inferior temporal surface area. Moreover, sex-by-resilience interactions were observed for gyrification in frontal and temporal regions. Our findings extend previous research by revealing that resilience is related to surface area and gyrification in frontal, occipital and temporal regions that are implicated in emotion regulation and face or object recognition.

Indexed as

Resilience, PsychologicalAdolescentCerebral CortexFemaleGray MatterHumansMagnetic Resonance ImagingMaleTemporal Lobeadolescentadversitybrain structurecortical thicknessresilience

Identifiers

PMID38287706
PMCPMC10868125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.