Evidence map›Paper›PMID 38287446›Full record

ArticleReproductive health2024

What is the impact of endometriosis and the AFS stage on cumulative pregnancy rates in IVF programs?

Karine Morcel, Philippe Merviel, Sarah Bouée, Mathilde Le Guillou, Marine Carlier, Pandora James, Hortense Drapier, Damien Beauvillard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Karine MorcelReproductive Medicine Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Philippe MervielReproductive Medicine Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France. philippe.merviel@chu-brest.fr.ORCID http://orcid.org/0000-0003-0184-0880
Sarah BouéeReproductive Medicine Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Mathilde Le GuillouReproductive Medicine Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Marine CarlierReproductive Medicine Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Pandora JamesReproductive Medicine Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Hortense DrapierReproductive Laboratory Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Damien BeauvillardReproductive Laboratory Department, ART Center, Brest University Medical Center, 2 Avenue Foch, 29200, Brest, France.
Centre Hospitalier Régional Universitaire de Brest · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometriosis is commonly observed in infertile women and can be staged with regard to severity [e.g. according to the American Fertility Society (AFS) classification]. This condition can cause infertility through impaired oocyte quality, fertilization disorders, tubal lesions, adhesions, deep infiltration, and adenomyosis. Although women with endometriosis often turn to in vitro fertilization (IVF) programs, the literature data on IVF outcomes are sometimes contradictory (i.e. the same as in other etiologies of infertility, or worse). The objective of the present study was to assess and compare pregnancy rates in women with and without endometriosis and according to the endometriosis stage.

methodsWe retrospectively studied clinical and ongoing pregnancy rates in IVF and the cumulative pregnancy rates after frozen/thawed embryo transfers, in women without endometriosis (group A) or with endometriosis (group B). We further compared groups in which endometriosis was staged according to the revised AFS classification: stage 1/2 (group C), stage 3/4 (group D, without endometrioma), and endometrioma alone (group E).

resultsWe documented 430 cycles in group A and 460 in group B (including 56 in group C, 88 in group D and 316 in group E). After fresh or frozen/thawed embryo transfers, the differences in ongoing pregnancy rates between groups A and B were not significant. However the cumulative rates per couple were significantly lower (p < 0.05) in group D.

conclusionsWe recommend IVF for women with endometriosis because the pregnancy rates are similar to those observed for women with other types of infertility. This approach is in line with the international guidelines issued by assisted reproductive technology societies. These results again raise the question of whether surgical resection of deep infiltrating endometriosis (stage 3/4) should be recommended before admission to an IVF program. Trial registration This study was approved by an institutional review board (CPP Ouest VI, Brest, France): reference: B2020CE.43.

Indexed as

EndometriosisInfertility, FemaleFemaleFertilityFertilization in VitroHumansPregnancyPregnancy OutcomePregnancy RateReproductive Techniques, AssistedRetrospective StudiesSperm Injections, IntracytoplasmicAFS stageEndometriomaEndometriosisIVFPregnancy rate

Identifiers

PMID38287446
PMCPMC10823753
OpenAlexW4391317520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.