ArticleBiological research2024
Embryo development is impaired by sperm mitochondrial-derived ROS.
Article in Biological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Integrated transcriptomic and metabolomic analysis of the hypothalamic-pituitary-testicular axis in rooster lines with contrasting hatchability.Poultry science · 2026Article
- Silydianin Improves the Preservation of Cooled Boar Semen.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Redefining success in assisted reproductive technologies: the Embryo-Maternal-Offspring Continuum Framework.Journal of assisted reproduction and genetics · 2026Review
- Protective Effect of Intracellular Compounds of Lactobacillus plantarum on Goat Sperm Quality During Cryopreservation.Veterinary medicine and science · 2026Article
- Predominance of Biliverdin over Bilirubin in Human Seminal Plasma.Biomolecules · 2026Article
- Cryptorchidism and infertility: what do we know so far?Asian journal of andrology · 2026Review
- Sperm Testing in Assisted Reproductive Technology: Diagnosis and Outcome Prediction.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- The Individual Variations in Sperm Quality of High-Fertility Boars Impact the Offspring Production and Early Physiological Functions.Veterinary sciences · 2025Article
- Oxidative Damage Under Microgravity Conditions: Response Mechanisms, Monitoring Methods and Countermeasures on Somatic and Germ Cells.International journal of molecular sciences · 2025Review
- The Sarcoplasmic/Endoplasmic reticulum CaScientific reports · 2025Article
- From Hypoxia to Oxidative Stress: Antioxidants' Role to Reduce Male Reproductive Damage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Mechanisms of oxidative stress-induced sperm dysfunction.Frontiers in endocrinology · 2025Review
- Extender development for optimal cryopreservation of buck sperm to increase reproductive efficiency of goats.Frontiers in veterinary science · 2025Review
- Contribution of the seminal microbiome to paternal programming.Biology of reproduction · 2024Review
- Heat shock protein 70 kDa (HSP70) is involved in the maintenance of pig sperm function throughout liquid storage at 17 °C.Scientific reports · 2024Article
- Article
- Abnormalities in mitochondrial energy metabolism induced by cryopreservation negatively affect goat sperm motility.Frontiers in veterinary science · 2024Article
- Redox Imbalance in Male Infertility: From Empirical Antioxidant Therapy to Precision Medicine and Epigenetic Insights.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBasal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development.
resultsWe first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation.
conclusionCollectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.