Evidence map›Paper›PMID 38287362›Full record

ArticleBMC medical genomics2024

Association of IL-10-592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes.

Raghda E Eldesouki, Rania M Kishk, Noha M Abd El-Fadeal, Rama I Mahran, Noha Kamel, Eman Riad, Nader Nemr, Safaa M Kishk, Eman Abdel-Moemen Mohammed

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Raghda E EldesoukiGenetics Unit, Histology Department, Faculty of Medicine, Suez Canal University, 41522, Ismailia, Egypt. reldeso122@gmail.com.
Rania M KishkMicrobiology and immunology Department, Faculty of Medicine, Suez Canal University, Ismaila, Egypt.
Noha M Abd El-FadealMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University, Ismaila, Egypt.
Rama I MahranClinical Pharmacology Department, Faculty of Medicine, Suez Canal University, Ismaila, Egypt.
Noha KamelClinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismaila, Egypt.
Eman RiadPulmonology Unit, Internal Medicine Department, Faculty of Medicine, Suez Canal University, Ismaila, Egypt.
Nader NemrEndemic and Infectious Diseases Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Safaa M KishkPharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Eman Abdel-Moemen MohammedGenetics Unit, Histology Department, Faculty of Medicine, Suez Canal University, 41522, Ismailia, Egypt.
Suez Canal University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVariation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved in innate viral response and cytokine storm emergence like IL-10 and TNFa gene polymorphisms. We hypothesize that IL-10; -592 C > A and - 1082 A > G and TNFa-308 G > A are associated with the risk of SARS-COV2 infections and clinical outcome.

methodsGenotyping, laboratory and radiological investigations were done to 110 COVID-19 patients and 110 healthy subjects, in Ismailia, Egypt.

resultsA significant association between the - 592 A allele, A containing genotypes under all models (p < 0.0001), and TNFa A allele with risk to infection was observed but not with the G allele of the - 1082. The - 592 /-1082 CG and the - 592 /-1082/ -308 CGG haplotypes showed higher odds in COVID-19 patients. Severe lung affection was negatively associated with - 592, while positive association was observed with - 1082. Higher D-dimer levels were strongly associated with the - 1082 GG genotype. Survival outcomes were strongly associated with the GA genotype of TNFa. -308 as well as AGG and AAA haplotypes.

conclusionIL-10 and TNFa polymorphisms should be considered for clinical and epidemiological evaluation of COVID-19 patients.

Indexed as

COVID-19Interleukin-10Gene FrequencyGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideRNA, ViralSARS-CoV-2Tumor Necrosis Factor-alphaIL10 protein, humanInterleukin-10RNA, ViralTNF protein, humanTumor Necrosis Factor-alphaCOVID-19EgyptGenotypeIL-10Innate immunityPharmacogenomicsPolymorphismRemdesivirrs1800629(-308)rs1800872 (− 592)rs1800896(− 1082)SARS-CoV-2SNPTNFa

Identifiers

PMID38287362
PMCPMC10826193
OpenAlexW4391310161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.