Evidence map›Paper›PMID 38287357›Full record

ArticleJournal of nanobiotechnology2024

Magnetic resonance imaging with upconversion nanoprobes capable of crossing the blood-cerebrospinal fluid barrier.

Fang Han, Jiahao Gao, Guanglei Lv, Tao Liu, Qingfeng Hu, Meilin Zhu, Zunguo Du, Jing Yang, Zhenwei Yao, Xiangming Fang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fang Han *Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Jiahao Gao *Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Guanglei Lv *Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P.R. China.
Tao LiuDepartment of Oncology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Qingfeng HuDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Meilin ZhuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Zunguo DuDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Jing YangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.
Xiangming FangDepartment of Medical Imaging, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214023, P.R. China. xiangming_fang@njmu.edu.cn.
Dalong NiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R. China. ndl12353@rjh.com.cn.
Jiawen ZhangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China. jiawen_zhang@fudan.edu.cn.

Funding

National Natural Science Foundation of China No. 82071877Natural Science Basic Research Plan of Shanxi No. 2022JQ-811the National Key Research and Development Project in China No. 2017YFC0113405
6 · The paper itself

Abstract

The central nervous system (CNS) maintains homeostasis with its surrounding environment by restricting the ingress of large hydrophilic molecules, immune cells, pathogens, and other external harmful substances to the brain. This function relies heavily on the blood-cerebrospinal fluid (B-CSF) and blood-brain barrier (BBB). Although considerable research has examined the structure and function of the BBB, the B-CSF barrier has received little attention. Therapies for disorders associated with the central nervous system have the potential to benefit from targeting the B-CSF barrier to enhance medication penetration into the brain. In this study, we synthesized a nanoprobe ANG-PEG-UCNP capable of crossing the B-CSF barrier with high targeting specificity using a hydrocephalus model for noninvasive magnetic resonance ventriculography to understand the mechanism by which the CSF barrier may be crossed and identify therapeutic targets of CNS diseases. This magnetic resonance nanoprobe ANG-PEG-UCNP holds promising potential as a safe and effective means for accurately defining the ventricular anatomy and correctly locating sites of CSF obstruction.

Indexed as

Blood-Brain BarrierBrainBiological TransportCentral Nervous SystemMagnetic Resonance ImagingBlood-brain barrierBlood-cerebrospinal fluid barrierMagnetic resonance imagingUpconversion nanoprobeVentriculography

Identifiers

PMID38287357
PMCPMC10826186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.