ArticleBMC infectious diseases2024
Clinical profile and outcomes of tetanus patients in a tertiary hospital in the Philippines: a ten-year retrospective study.
Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Non-Neonatal Tetanus in Mogadishu, Somalia: Clinical Characteristics, Management, and Outcomes-First Report from a Tetanus Referral Centre.Tropical medicine and infectious disease · 2026Article
- 10 years trends and hospitalization outcomes of non-neonatal tetanus: a large-scale multicenter retrospective study in China.Critical care (London, England) · 2026Article
- Mortality and Associated Factors Among Adult Tetanus Patients Admitted at Public Hospitals in Bahir Dar City, Ethiopia: A Cross-Sectional Study.Health science reports · 2026Article
- Analysis of 92 hospitalized cases of non-neonatal tetanus in Guizhou Province, China.Frontiers in public health · 2026Article
- Clinically diagnosed tetanus in a 58-year-old female with breast fungating mass.Tropical medicine and health · 2025Article
- Tetanus: recognition and management.The Lancet. Infectious diseases · 2025Review
- Tetanus in Romania-Trends and Challenges.Microorganisms · 2025Article
- Systemic immune inflammation index as a predictor of disease severity in tetanus patients: A retrospective observational study.PloS one · 2024Observational
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTetanus is a life-threatening but preventable neurologic disorder characterized by trismus and muscle spasms. Despite its decreasing global incidence, it remains to be endemic in resource-limited settings such as the Philippines. This study aimed to determine the incidence, demographic characteristics, risk factors, clinical presentation, management, complications, and outcomes of non-neonatal tetanus cases in a tertiary hospital in the Philippines. It also aimed to compare the clinical profile and outcomes between the adult and pediatric subgroups.
methodsThis study used a retrospective cross-sectional design including all adult and pediatric non-neonatal tetanus patients admitted at the University of the Philippines - Philippine General Hospital from January 2012 to June 2023. Data was extracted from department censuses and inpatient charts.
resultsOne hundred thirty-eight cases were included. The incidence rate was 0.03%, while mortality rate was 29%. Majority of patients were males presenting with trismus and spasms after sustaining a puncture wound. Chronic hypertension was associated with an increased hazard of death by 4.5 times (p = 0.004), while treatment with magnesium sulfate was associated with a decreased hazard of death by 35 times (p = 0.005). The mode of infection and the medications administered differed between the adult and pediatric subgroups.
conclusionsAlthough the total number of cases has decreased over the past decade, tetanus remains to have a high incidence and mortality rate in the Philippines. Increasing vaccination coverage, improving public awareness, and educating health professionals can help reduce morbidity and mortality from this disease.
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