Evidence map›Paper›PMID 38287144›Full record

ArticleCommunications medicine2024

Generative deep learning furthers the understanding of local distributions of fat and muscle on body shape and health using 3D surface scans.

Lambert T Leong, Michael C Wong, Yong E Liu, Yannik Glaser, Brandon K Quon, Nisa N Kelly, Devon Cataldi, Peter Sadowski, Steven B Heymsfield, John A Shepherd

Abstract read
In one paragraph

Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lambert T LeongMolecular Bioscience and Bioengineering at University of Hawaii, Honolulu, HI, USA.ORCID http://orcid.org/0000-0002-2927-8458
Michael C WongDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Yong E LiuDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Yannik GlaserInformation and Computer Science at University of Hawaii, Honolulu, HI, USA.ORCID http://orcid.org/0000-0001-7217-9749
Brandon K QuonDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Nisa N KellyDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Devon CataldiDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Peter SadowskiInformation and Computer Science at University of Hawaii, Honolulu, HI, USA.ORCID http://orcid.org/0000-0002-7354-5461
Steven B HeymsfieldPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LO, USA.ORCID http://orcid.org/0000-0003-1127-9425
John A ShepherdMolecular Bioscience and Bioengineering at University of Hawaii, Honolulu, HI, USA. johnshep@hawaii.edu.ORCID http://orcid.org/0000-0003-2280-2541

Funding

AIM-AHEAD Coordinating Center - All Four CoresOT2OD032581 · OD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Paul Avillach, Bettina M. Beech · 2021 to 2026
$168.7M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Optical Body Composition and Health AssessmentR01DK109008 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI HEYMSFIELD, STEVEN, SHEPHERD, JOHN ALAN · 2016 to 2020
$3.2M
Multidisciplinary Training in Ethnic Diversity and Cancer DisparitiesT32CA229110 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2019 to 2023
$2.1M
NCI NIH HHS P30 CA071789NCI NIH HHS T32 CA229110NHLBI NIH HHS T32 HL115505NIDDK NIH HHS R01 DK109008NIH HHS OT2 OD032581
6 · The paper itself

Abstract

backgroundBody shape, an intuitive health indicator, is deterministically driven by body composition. We developed and validated a deep learning model that generates accurate dual-energy X-ray absorptiometry (DXA) scans from three-dimensional optical body scans (3DO), enabling compositional analysis of the whole body and specified subregions. Previous works on generative medical imaging models lack quantitative validation and only report quality metrics.

methodsOur model was self-supervised pretrained on two large clinical DXA datasets and fine-tuned using the Shape Up! Adults study dataset. Model-predicted scans from a holdout test set were evaluated using clinical commercial DXA software for compositional accuracy.

resultsPredicted DXA scans achieve R

conclusionsThis work highlights the potential of generative models in medical imaging and reinforces the importance of quantitative validation for assessing their clinical utility.

Identifiers

PMID38287144
PMCPMC10824755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.