Evidence map›Paper›PMID 38287121›Full record

ArticleScientific reports2024

Neurochemical differences in core regions of the autistic brain: a multivoxel

Ana Dionísio, Ana Espírito, Andreia C Pereira, Susana Mouga, Otília C d'Almeida, Guiomar Oliveira, Miguel Castelo-Branco

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. GABA and glutamate measurements in temporal cortex of autistic children.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Dionísio *Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Ana Espírito *Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Andreia C PereiraCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Susana MougaCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Otília C d'AlmeidaCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Guiomar OliveiraCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.
Miguel Castelo-BrancoCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal. mcbranco@fmed.uc.pt.

Funding

Fundação para a Ciência e a Tecnologia COVDATA - DSAIPA/DS/0041/2020
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition which compromises various cognitive and behavioural domains. The understanding of the pathophysiology and molecular neurobiology of ASD is still an open critical research question. Here, we aimed to address ASD neurochemistry in the same time point at key regions that have been associated with its pathophysiology: the insula, hippocampus, putamen and thalamus. We conducted a multivoxel proton magnetic resonance spectroscopy (

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentAspartic AcidBrainChildCholineCreatineGlutamic AcidGlutamineHumansMaleReceptors, Antigen, T-CellAspartic AcidCholineCreatineGlutamic AcidGlutamineReceptors, Antigen, T-Cell

Identifiers

PMID38287121
PMCPMC10824733

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.