Evidence map›Paper›PMID 38287106›Full record

ArticlePediatric research2024

International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward.

Caroline L H Brackel, Lieke C E Noij, Susanne J H Vijverberg, Camille L Legghe, Anke H Maitland-van der Zee, Johannes B van Goudoever, Danilo Buonsenso, Daniel Munblit, Louise Sigfrid, Sammie McFarland and 51 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors at 20 institutions in 15 countries.

Caroline L H Brackel *Department of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. C.l.brackel@amsterdamumc.nl.
Lieke C E Noij *Department of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
Susanne J H VijverbergDepartment of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
Camille L LeggheDepartment of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
Anke H Maitland-van der ZeeDepartment of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
Johannes B van GoudoeverDepartment of Pediatrics, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
Danilo BuonsensoDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Daniel MunblitCare for Long Term Conditions Division, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Louise SigfridISARIC Global Support Centre, Pandemic Science Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Sammie McFarlandLong COVID Kids and Friends, Fletcher & Partners, Crown Chambers, Bridge Street, Salisbury, SP1 2LZ, UK.
Lena AnmyrMedical Unit Social Work, Function Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
Liat Ashkenazi-HoffnungDepartment of Day Hospitalization, Schneider Children's Medical Center, Petach Tikva, Tel Aviv, Israel.
Ana P N BellinatPediatric Intensive Care Unit, Hospital Martagão Gesteira - Children's Hospital, Salvador, Brazil.
Nathália L S DiasPediatric Intensive Care Unit, Hospital Martagão Gesteira - Children's Hospital, Salvador, Brazil.
Amy EdwardsDepartment of Infectious Disease, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Tomini FashinaDepartment of Global Health, Yale University School of Public Health, New Haven, CT, USA.
Romana Gjergja JuraškiDepartment of Pediatric Neurology, Srebrnjak Children's Hospital, Srebrnjak, Zagreb, Croatia.
Ana L N GonçalvesUniversidade Católica de Pernambuco, Recife, Pernambuco, Brazil.
Edita HanstedDepartment of Pediatrics, Lithuanian University of Health Sciences Hospital KaunoKlinikos, Kaunas, Lithuania.
Vivien HerczegPediatric Center, MTA Center of Excellence, Semmelweis University, Bókay Unit, Budapest, Hungary.
Olof HerttingDepartment of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Lina N JankauskaiteDepartment of Pediatrics, Lithuanian University of Health Sciences Hospital KaunoKlinikos, Kaunas, Lithuania.
Nastiti KaswandaniDepartment of Child Health, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Rimantas KevalasDepartment of Pediatrics, Lithuanian University of Health Sciences Hospital KaunoKlinikos, Kaunas, Lithuania.
Péter KrivácsyPediatric Center, MTA Center of Excellence, Semmelweis University, Bókay Unit, Budapest, Hungary.
Michael LorenzPediatric Pulmonology, Department of Paediatrics, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Laura A MaloneDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Molly McVoyDepartment of Pediatric Psychiatry, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
David W MillerDepartment of Pediatric Integrative Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Amanda K MorrowDepartment of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Manjula D NugawelaUCL Great Ormond Street Institute of Child Health, London, UK.
Carlos R OliveiraDepartment of Pediatrics, Division of Infectious Diseases & Global Health, Yale University School of Medicine, New Haven, CT, USA.
Pablo R S OliveiraInstitute of Biology, Federal University of Bahia, Salvador, Brazil.
Ismael M OsmanovZA Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.
Isabella M OvermarsDepartment of Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Melbourne, VIC, Australia.
Elijah PaintsilDepartment of Pediatrics, Division of Infectious Diseases & Global Health, Yale University School of Medicine, New Haven, CT, USA.
Snehal M Pinto PereiraDivision of Surgery & Interventional Science, University College London, London, UK.
Yogi PrawiraDepartment of Child Health, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Nina Dwi PutriDepartment of Child Health, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Regina C F RamosHospital Universitário Oswaldo Cruz, Recife, Pernambuco, Brazil.
Marius RaschePediatric Pulmonology, Department of Paediatrics, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Malin Ryd-RinderPediatric Emergency Care, Astrid Lindgren Children Hospital, Karolinska University Hospital, Stockholm, Sweden.
Christina De RoseDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Elmira SamitovaZA Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.
Tatjana Savić JovanovićIntensive Care Unit, Srebrnjak Children's Hospital Zagreb, Zagreb, Croatia.
Daniela SayDepartment of Infection and Immunity, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Melbourne, VIC, Australia.
Janet T ScottDepartment of Infectious Disease, MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Iris Shachar-LavieDepartment of Psychological Medicine, Schneider Children's Medical Center, Petach Tikva, Israel.
Roz ShafranUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Einat ShmueliPulmonary Institute, Schneider Children's Medical Center, Petach Tikva, Tel Aviv, Israel.
Ausra SnipaitieneDepartment of Pediatrics, Lithuanian University of Health Sciences Hospital KaunoKlinikos, Kaunas, Lithuania.
Terence StephensonUCL Great Ormond Street Institute of Child Health, University College Hospital & Great Ormond Street Hospital, London, UK.
Nikolett TénaiPediatric Center, MTA Center of Excellence, Semmelweis University, Bókay Unit, Budapest, Hungary.
Shidan TosifDepartment of General Medicine, Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Melbourne, Australia.
Mirjana TurkaljDepartment of Pulmonology, Allergy and Immunology, Srebrnjak Children's Hospital, Zagreb, Croatia.
Piero ValentiniDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Luydson R S VasconcelosHospital Universitário Oswaldo Cruz, Recife, Pernambuco, Brazil.
Li VillardMedical Unit Occupational Therapy and Physiotherapy, Function Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
Daniel VilserClinic for Pediatric and Adolescent Medicine Neuberg/Ingolstadt AMEOS Hospital Association, Neuberg, Germany.
Simone HashimotoDepartment of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
Suzanne W J Terheggen-LagroDepartment of Pediatric Pulmonology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands.
University of Amsterdam · NLLithuanian University of Health Sciences · LTAgostino Gemelli University Polyclinic · ITKarolinska University Hospital · SERainbow Babies & Children's Hospital · USSchneider Children's Medical Center · ILSemmelweis University · HUUniversity College London · GBYale University · USChildren's Hospital Zagreb · HREmma Kinderziekenhuis · NLHospital São Rafael · BRJohns Hopkins Medicine · USRoyal Children's Hospital · AURumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo · IDAgricultural Institute Osijek · HRAmeos Klinikum Inntal · DEFriedrich Schiller University Jena · DEFundação Oswaldo Cruz · BRHospital Universitário Oswaldo Cruz · BR

Funding

Clinical Epidemiology of Pediatric COVID-19 and MIS-CK23AI159518 · NIAID · YALE UNIVERSITY · PI OLIVEIRA, CARLOS RAFAEL · 2021 to 2024
$729k
Medical Research Council MR/P020372/1NIAID NIH HHS K23 AI159518Wellcome Trust
6 · The paper itself

Abstract

backgroundPediatric Post-COVID-Condition (PPCC) clinics treat children despite limited scientific substantiation. By exploring real-life management of children diagnosed with PPCC, the International Post-COVID-Condition in Children Collaboration (IP4C) aimed to provide guidance for future PPCC care.

methodsWe performed a cross-sectional international, multicenter study on used PPCC definitions; the organization of PPCC care programs and patients characteristics. We compared aggregated data from PPCC cohorts and identified priorities to improve PPCC care.

resultsTen PPCC care programs and six COVID-19 follow-up research cohorts participated. Aggregated data from 584 PPCC patients was analyzed. The most common symptoms included fatigue (71%), headache (55%), concentration difficulties (53%), and brain fog (48%). Severe limitations in daily life were reported in 31% of patients. Most PPCC care programs organized in-person visits with multidisciplinary teams. Diagnostic testing for respiratory and cardiac morbidity was most frequently performed and seldom abnormal. Treatment was often limited to physical therapy and psychological support.

conclusionsWe found substantial heterogeneity in both the diagnostics and management of PPCC, possibly explained by scarce scientific evidence and lack of standardized care. We present a list of components which future guidelines should address, and outline priorities concerning PPCC care pathways, research and international collaboration. IMPACT: Pediatric Post-COVID Condition (PPCC) Care programs have been initiated in many countries. Children with PPCC in different countries are affected by similar symptoms, limiting many to participate in daily life. There is substantial heterogeneity in diagnostic testing. Access to specific diagnostic tests is required to identify some long-term COVID-19 sequelae. Treatments provided were limited to physical therapy and psychological support. This study emphasizes the need for evidence-based diagnostics and treatment of PPCC. The International Post-COVID Collaboration for Children (IP4C) provides guidance for guideline development and introduces a framework of priorities for PPCC care and research, to improve PPCC outcomes.

Indexed as

COVID-19Post-Acute COVID-19 SyndromeAdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantMale

Identifiers

PMID38287106
PMCPMC12378996
OpenAlexW4391323813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.