ArticleNature communications2024
Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Wolbachia strain wLhui induces temperature-dependent incomplete cytoplasmic incompatibility in the invasive pest Liriomyza huidobrensis with biocontrol potential.Pest management science · 2026Article
- Establishment and characterization of a Wolbachia (wAlbB)-infected Aedes aegypti line (Tw-Kao) for dengue control.PLoS neglected tropical diseases · 2026Article
- The symbiotic Wolbachia in Anopheles and its role in reducing the transmission of Plasmodium: updates and prospects.Archives of microbiology · 2026Review
- Article
- Deubiquitylases and nucleases in bacterial symbiont-induced cytoplasmic incompatibility.Biochemical Society transactions · 2025Review
- Wolbachia-mediated reproductive manipulation in rice planthoppers.Crop health · 2025Review
- Diversity and spread of cytoplasmic incompatibility genes among maternally inherited symbionts.PLoS genetics · 2025Article
- Comparative genomics and transcriptomics of theResearch square · 2025Article
- Both maternal and paternal genotypes modulate Wolbachia-induced cytoplasmic incompatibility in graham bean beetles.Heredity · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Gene drive-based population suppression in the malaria vector Anopheles stephensi.Nature communications · 2025Article
- Addictive manipulation: a perspective on the role of reproductive parasitism in the evolution of bacteria-eukaryote symbioses.Biology letters · 2024Review
- Review
- Intra-lineage microevolution of Wolbachia leads to the emergence of new cytoplasmic incompatibility patterns.PLoS biology · 2024Article
- Insecticide susceptibility in a planthopper pest increases following inoculation with cultured Arsenophonus.The ISME journal · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The endosymbiotic bacteria Wolbachia can invade insect populations by modifying host reproduction through cytoplasmic incompatibility (CI), an effect that results in embryonic lethality when Wolbachia-carrying males mate with Wolbachia-free females. Here we describe a transgenic system for recreating CI in the major arbovirus vector Aedes aegypti using CI factor (cif) genes from wAlbB, a Wolbachia strain currently being deployed to reduce dengue transmission. CI-like sterility is induced when cifA and cifB are co-expressed in testes; this sterility is rescued by maternal cifA expression, thereby reproducing the pattern of Wolbachia-induced CI. Expression of cifB alone is associated with extensive DNA damage and disrupted spermatogenesis. The strength of rescue by maternal cifA expression is dependent on the comparative levels of cifA/cifB expression in males. These findings are consistent with CifB acting as a toxin and CifA as an antitoxin, with CifA attenuating CifB toxicity in both the male germline and in developing embryos. These findings provide important insights into the interactions between cif genes and their mechanism of activity and provide a foundation for the building of a cif gene-based drive system in Ae. aegypti.
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