Evidence map›Paper›PMID 38286946›Full record

ReviewNeurocritical care2024

Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap.

Nicholas D Schiff, Michael Diringer, Karin Diserens, Brian L Edlow, Olivia Gosseries, N Jeremy Hill, Leigh R Hochberg, Fatima Y Ismail, Ivo A Meyer, Charles B Mikell and 6 more

Open access · greenAbstract readReview
In one paragraph

Review in Neurocritical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Ethical Considerations in Transcranial Focused Ultrasound Neuromodulation for Disorders of Consciousness.Neuromodulation : journal of the International Neuromodulation Society · 2026
    Article
  4. Article
  5. Review
  6. Eye movements as indicators of awareness in prolonged disorders of consciousness: a scoping review of behavioral and neural evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 6 countries.

Nicholas D SchiffFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA. nds2001@med.cornell.edu.ORCID 0000-0003-0008-426X
Michael DiringerDepartments of Neurology and Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA.
Karin DiserensNeurology and Acute Neurorehabilitation Unit, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Brian L EdlowCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Olivia GosseriesComa Science Group, GIGA-Consciousness, Centre du Cerveau, University Hospital of Liège, University of Liège & Centre du Cerveau, Liège, Belgium.
N Jeremy HillNational Center for Adaptive Neurotechnologies, Stratton VA Medical Center, Albany, NY, USA.
Leigh R HochbergVeterans Affairs Rehabilitation Research & Development Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development Service, Providence VA Medical Center, Providence, RI, USA.
Fatima Y IsmailDepartment of Pediatrics, United Arab Emirates University, Al Ain, United Arab Emirates.
Ivo A MeyerNeurology and Acute Neurorehabilitation Unit, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Charles B MikellDepartment of Neurosurgery, Stony Brook University Hospital, Stony Brook, NY, USA.
Sima MofakhamDepartment of Neurosurgery, Stony Brook University Hospital, Stony Brook, NY, USA.
Erika MolteniSchool of Biomedical Engineering and Imaging Sciences, and Centre for Medical Engineering, King's College London, London, UK.
Leonard PolizzottoDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Sudhin A ShahDepartment of Radiology, Weill Cornell Medical College, New York, NY, USA.
Robert D StevensDepartments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Daniel ThengoneBrown University, Providence, RI, USA.
Cornell University · USJohns Hopkins University · USStony Brook University Hospital · USAlbany State University · USAllen Institute for Brain Science · USBrown University · USCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal · CAHarvard University · USKing's College London · GBUniversity of Lausanne · CHUniversity of Liège · BEWashington University in St. Louis · USWorcester Polytechnic Institute · US

Funding

Training and DisseminationP41EB018783 · NIBIB · WADSWORTH CENTER · PI Theresa M. Vaughan · 2014 to 2026
$15.4M
A Connectome-Based Clinical Trial Platform to Promote Early Recovery of Consciousness after Traumatic ComaDP2HD101400 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, BRIAN L. · 2019 to 2019
$2.5M
Dynamics and Causal Functions of Large-Scale Cortical and Subcortical NetworksU01NS108916 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 2018 to 2019
$1.4M
NIBIB NIH HHS P41 EB018783NICHD NIH HHS DP2 HD101400NINDS NIH HHS U01 NS108916
6 · The paper itself

Abstract

backgroundWe developed a gap analysis that examines the role of brain-computer interfaces (BCI) in patients with disorders of consciousness (DoC), focusing on their assessment, establishment of communication, and engagement with their environment.

methodsThe Curing Coma Campaign convened a Coma Science work group that included 16 clinicians and neuroscientists with expertise in DoC. The work group met online biweekly and performed a gap analysis of the primary question.

resultsWe outline a roadmap for assessing BCI readiness in patients with DoC and for advancing the use of BCI devices in patients with DoC. Additionally, we discuss preliminary studies that inform development of BCI solutions for communication and assessment of readiness for use of BCIs in DoC study participants. Special emphasis is placed on the challenges posed by the complex pathophysiologies caused by heterogeneous brain injuries and their impact on neuronal signaling. The differences between one-way and two-way communication are specifically considered. Possible implanted and noninvasive BCI solutions for acute and chronic DoC in adult and pediatric populations are also addressed.

conclusionsWe identify clinical and technical gaps hindering the use of BCI in patients with DoC in each of these contexts and provide a roadmap for research aimed at improving communication for adults and children with DoC, spanning the clinical spectrum from intensive care unit to chronic care.

Indexed as

Brain-Computer InterfacesConsciousness DisordersCommunicationHumansCognitive motor dissociationComaCommunicationElectroencephalographyFunctional magnetic resonance imagingHead injuryNeural repair

Identifiers

PMID38286946
PMCPMC11284251
OpenAlexW4391304009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.