Evidence map›Paper›PMID 38286871›Full record

ArticlePediatric surgery international2024

Neurodevelopmental impairment following surgical necrotizing enterocolitis with gestational age ≥ 28 weeks: who is at risk?

Shuai Shang, Lijia Du, Na Geng, Yingchao Li, Suolin Li, Ao Li, Cuncun Shen, Lintao Liu, Weili Xu

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shuai ShangDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Lijia DuDepartment of Gynecology and Obstetrics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Na GengDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Yingchao LiDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Suolin LiDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Ao LiDepartment of Pediatric Surgery, Maternity Hospital of Shijiazhuang City Affiliated to Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Cuncun ShenDepartment of Pediatric Surgery, Maternity Hospital of Shijiazhuang City Affiliated to Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Lintao LiuDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China.
Weili XuDepartment of Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China. drwlxu@yeah.net.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSurgical necrotizing enterocolitis (NEC) is a severe medical condition that, even after surgery, a portion of the survival infants may still have neurological sequelae. The objective of this study was to identify the risk factors associated with the development of permanent neurodevelopmental impairment (NDI) in neonates with surgical NEC.

methodsBetween January 2016 and June 2022, a retrospective data collection was conducted on 98 individuals who experienced surgical NEC with gestational age ≥ 28 weeks. Among these patients, 27 patients were diagnosed with NDI, while the remaining 71 patients did not have NDI. Based on this division, the patients were categorized into the NDI group and the Non-NDI group. Demographics, comorbidities, and admission lab results were analyzed using univariate and logistic regression analyses.

resultsOf the 98 neonates following surgical NEC, 27(27.6%) developed permanent neurodevelopmental impairment (NDI). Predictors of NDI were identified through the final multivariable logistic regression analysis, which revealed that gestational age ≤ 32 weeks (p = 0.032; odds ratio [OR], 5.673), assisted mechanical ventilation after NEC onset (p = 0.047; OR, 5.299), postoperative acute kidney injury (p = 0.040; OR, 5.106), CRP day 3 after NEC onset (p = 0.049; OR, 1.037), time from presentation to surgery (p = 0.003; OR, 1.047) were significant risk factors.

conclusionsOur study identified gestational age ≤ 32 weeks, assisted mechanical ventilation after NEC onset, postoperative acute kidney injury, CRP day 3 after NEC onset, and time from presentation to surgery as significant risk factors for NDI in neonates with surgical NEC. These factors would be helpful to refine treatment modalities for better disease outcomes. We also determined the cut-off values of CRP day 3 after NEC onset and time from presentation to surgery, allowing for the individualized evaluation of NDI risk and the implementation of earlier targeted laparotomy.

Indexed as

Acute Kidney InjuryEnterocolitis, NecrotizingFetal DiseasesInfant, Newborn, DiseasesFemaleGestational AgeHumansInfantInfant, NewbornRetrospective StudiesRisk FactorsCRPNeurodevelopmental impairment (NDI)Postoperative acute kidney injury(AKI)Surgical necrotizing enterocolitis (NEC)Time from presentation to surgery

Identifiers

PMID38286871
OpenAlexW4391324300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.