Evidence map›Paper›PMID 38286689›Full record

ArticleBMJ open2024

'Effects of a home-based bimodal lifestyle intervention in frail patients with end-stage liver disease awaiting orthotopic liver transplantation': study protocol of a non-randomised clinical trial.

Allard G Wijma, Bart C Bongers, Coby Annema, Rienk Dekker, Hans Blokzijl, Job Am van der Palen, Vincent E De Meijer, Frans Jc Cuperus, Joost M Klaase

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05853484 (FIT4Cirrhotics@Home), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05853484 naunknown statusnot on this map

FIT4Cirrhotics@Home: Effects of a Home-based Bimodal Lifestyle Intervention in Patients With Liver Cirrhosis Awaiting Orthotopic Liver Transplantation

TypeinterventionalSponsorUniversity Medical Center GroningenRan2024 to 2025Enrolled16ConditionsLiver Cirrhosis, Liver Transplant, Complications, Physical InactivityArmsBimodal lifestyle program
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Allard G WijmaDepartment of Surgery, division of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands a.g.wijma@umcg.nl.ORCID 0000-0003-4227-4715
Bart C BongersDepartment of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-1948-9788
Coby AnnemaSection of Nursing Science, Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0001-8663-2145
Rienk DekkerDepartment for Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-6649-6289
Hans BlokzijlDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-4240-7506
Job Am van der PalenDepartment of Epidemiology, Medisch spectrum Twente, Enschede, Netherlands.ORCID 0000-0003-1071-6769
Vincent E De MeijerDepartment of Surgery, division of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0002-7900-5917
Frans Jc CuperusDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-6742-1510
Joost M KlaaseDepartment of Surgery, division of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0002-4409-2280
University Medical Center Groningen · NLMaastricht University · NLMedisch Spectrum Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients with end-stage liver disease awaiting orthotopic liver transplantation (OLT) are generally classified as frail due to disease-related malnutrition and a progressive decline in musculoskeletal and aerobic fitness, which is associated with poor pre-OLT, peri-OLT and post-OLT outcomes. However, frailty in these patients may be reversable with adequate exercise and nutritional interventions. METHODS AND ANALYSIS: Non-randomised clinical trial evaluating the effect of a home-based bimodal lifestyle programme in unfit patients with a preoperative oxygen uptake (VO ETHICS AND DISSEMINATION: This study was approved by the Medical Research Ethics Committee of the UMCG (registration number NL83612.042.23, August 2023) and is registered in the Clinicaltrials.gov register (NCT05853484). Good Clinical Practice guidelines and the principles of the Declaration of Helsinki will be applied. Results of this study will be submitted for presentation at (inter)national congresses and publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT05853484.

Indexed as

End Stage Liver DiseaseLiver TransplantationAgedClinical Trials as TopicExercise TherapyFrail ElderlyHumansLife StyleQuality of LifeGASTROENTEROLOGYHepatologyREHABILITATION MEDICINESURGERYTransplant surgery

Identifiers

PMID38286689
PMCPMC10826538
OpenAlexW4391330485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.