Evidence map›Paper›PMID 38286567›Full record

ArticleBMJ open ophthalmology2024

Effect of the gut microbiome in glaucoma risk from the causal perspective.

Yaxuan Wu, Ronghua Shi, He Chen, Zicheng Zhang, Siqi Bao, Jia Qu, Meng Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Role of gut microbiomes in different ocular pathologies: A systematic review.World journal of gastrointestinal pathophysiology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Meeting Challenges in the Diagnosis and Treatment of Glaucoma.Bioengineering (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yaxuan WuSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People's Republic of China.
Ronghua ShiSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People's Republic of China.
He ChenSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People's Republic of China.
Zicheng ZhangSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People's Republic of China.
Siqi BaoSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People's Republic of China.
Jia QuSchool of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, People's Republic of China zhoumeng@wmu.edu.cn qujia@eye.ac.cn.ORCID 0000-0001-6360-2568
Meng ZhouNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, People's Republic of China zhoumeng@wmu.edu.cn qujia@eye.ac.cn.ORCID 0000-0001-9987-9024
Hainan University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEvidence from observational studies has reported possible associations between the gut microbiome (GM) and glaucoma. However, the causal effect of GM on glaucoma risk remains to be determined. METHODS AND ANALYSIS: We conducted two-sample bidirectional Mendelian randomisation (MR) analyses to explore the causal association between GM and glaucoma. Genome-wide association study summary statistics of 196 GM taxa (n=18 340) and glaucoma (18 902 cases and 358 375 controls) were obtained from MiBioGen and FinnGen Consortium. Inverse variance weighted, MR-Egger, weighted median, weighted mode, Mendelian Randomisation Pleiotropy Residual Sum and Outlier, MR-Egger intercept and Cochran's Q statistical analyses were used to supplement MR results and sensitivity analysis. An independent cohort from the Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol (MRC-IEU) Consortium (1715 cases and 359 479 controls) was used to validate causal effects.

resultsResults of the MR analysis suggested that the family

conclusionThis MR analysis from large population studies demonstrated the causal effect of GM on glaucoma risk and supported the role of GM in influencing glaucoma susceptibility.

Indexed as

ActinobacteriaGastrointestinal MicrobiomeGlaucomaCausalityGenome-Wide Association StudyHumansMendelian Randomization Analysisglaucomamicrobiology

Identifiers

PMID38286567
PMCPMC10826588
OpenAlexW4391309039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.