Evidence map›Paper›PMID 38286187›Full record

ArticleThe Journal of investigative dermatology2024

Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice.

Maria Strakosha, Daniela Vega-Mendoza, Jennifer Kane, Ashish Jain, Liang Sun, Shira Rockowitz, Megan Elkins, Kensuke Miyake, Janet Chou, Hajime Karasuyama and 2 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of investigative dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. IL-4 acts on skin-derived dendritic cells to promote the TThe Journal of allergy and clinical immunology · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Maria StrakoshaDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Daniela Vega-MendozaDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jennifer KaneDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ashish JainResearch Computing, Information Technology, Boston Children's Hospital, Boston, Massachusetts, USA.
Liang SunResearch Computing, Information Technology, Boston Children's Hospital, Boston, Massachusetts, USA.
Shira RockowitzResearch Computing, Information Technology, Boston Children's Hospital, Boston, Massachusetts, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA; The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Megan ElkinsDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kensuke MiyakeInflammation, Infection and Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Janet ChouDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hajime KarasuyamaInflammation, Infection and Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Raif S GehaDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Juan-Manuel Leyva-CastilloDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: Manuel.LeyvaCastillo@childrens.harvard.edu.
Boston Children's Hospital · USTokyo Medical and Dental University · JP

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI LEUNG, DONALD YM · 2015 to 2019
$30.6M
Mechanisms of food allergy elicited by cutaneous sensitizationR01AI113294 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GEHA, RAIF SALIM · 2016 to 2019
$2.1M
NCI NIH HHS P30 CA006516NIAID NIH HHS R01 AI113294NIAID NIH HHS U19 AI117673
6 · The paper itself

Abstract

Physical trauma disrupts skin barrier function. How the skin barrier recovers is not fully understood. We evaluated in mice the mechanism of skin barrier recovery after mechanical injury inflicted by tape stripping. Tape stripping disrupted skin barrier function as evidenced by increased transepidermal water loss. We show that tape stripping induces IL-1-, IL-23-, and TCRγδ

Indexed as

BasophilsInterleukin-17InterleukinsAnimalsDisease Models, AnimalEpidermisFemaleInterleukin-22MiceMice, Inbred C57BLMice, KnockoutNeutrophil InfiltrationRecovery of FunctionSkinWater Loss, InsensibleIl17a protein, mouseInterleukin-17Interleukin-22InterleukinsBasophilsIL-17ANeutrophilsSkin barrier

Identifiers

PMID38286187
PMCPMC11260541
OpenAlexW4391288632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.