Evidence map›Paper›PMID 38286127›Full record

ArticlePsychopathology2024

Temperament Traits in Pediatric Obsessive-Compulsive Disorder in Relation to Tourette Syndrome and Attention-Deficit Hyperactivity Disorder.

Jessica Szu-Chi Cheng, Elissa Khalil, Masoud Salehi, Lauren Mulcahy, Isabella Yiru Xie, Hasti Hadizadeh, Marco A Grados

Open access · greenAbstract read
In one paragraph

Article in Psychopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jessica Szu-Chi ChengDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Elissa KhalilFaculty of Medicine, American University of Beirut, Beirut, Lebanon.
Masoud SalehiDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Lauren MulcahyDivision of Molecular Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Isabella Yiru XieClinical Psychology, Palo Alto University, Palo Alto, California, USA.
Hasti HadizadehDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USUniversity of Minnesota · USAmerican University of Beirut · LBPalo Alto University · US

Funding

LINKAGE &ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDERK23MH066284 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRADOS, MARCO A · 2002 to 2006
$887k
NIMH NIH HHS K23 MH066284
6 · The paper itself

Abstract

introductionPediatric obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS) are often concurrent. This study explores the temperament profile of complex OCD phenotypes.

methodsA clinical registry recorded demographic data, psychiatric diagnoses, and temperament traits, including novelty seeking (exploratory behaviors), harm avoidance (fear of uncertainty), reward dependence (sentimentality), and persistence (perseverance). Temperament data were accrued from the Junior Temperament and Character Inventory (JTCI). Participants were divided into (1) OCD only; (2) OCD+ADHD or TS; and (3) OCD+ADHD+TS to compare temperament.

resultsParticipants include 126 youths with OCD (61.9% male, 88.9% white) between the ages 6 and 18 years (12.7 ± 3.1). Among the three groups, the complex neurodevelopmental disorder group OCD+ADHD+TS expresses the highest novelty seeking and lowest persistence. Harm avoidance is increased in all groups compared to reference controls, irrespective of concurrent ADHD or TS. For the OCD+ADHD+TS group, contamination and washing symptoms have higher novelty seeking (p < 0.01), while counting and ordering have lower novelty seeking (p < 0.05). Harm avoidance is increased with aggressive, somatic, and checking symptoms in OCD only (p < 0.01), while persistence is increased with repeating and counting symptoms in the comorbid groups (OCD+ADHD or TS, OCD+ADHD+TS). DISCUSSION/

conclusionThe complex subtype, OCD+ADHD+TS, is associated with high novelty seeking and low persistence, while high harm avoidance is linked to pediatric OCD irrespective of ADHD or TS co-occurrence. In sum, pediatric OCD with ADHD and TS confers a unique temperament profile, further refining complex phenotypes of pediatric OCD for future research.

Indexed as

Attention Deficit Disorder with HyperactivityObsessive-Compulsive DisorderTemperamentTourette SyndromeAdolescentChildComorbidityExploratory BehaviorFemaleHumansMaleAttention-deficit hyperactivity disorderMotor inhibitionObsessive-compulsive disorderTemperamentTourette syndrome

Identifiers

PMID38286127
PMCPMC11147693
OpenAlexW4391302382

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.