Evidence map›Paper›PMID 38286121›Full record

ArticleDevelopmental neuroscience2024

Pain/Stress, Mitochondrial Dysfunction, and Neurodevelopment in Preterm Infants.

Tingting Zhao, Xiaolin Chang, Subrata Kumar Biswas, Jeremy L Balsbaugh, Jennifer Liddle, Ming-Hui Chen, Adam P Matson, Nathan N Alder, Xiaomei Cong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tingting ZhaoSchool of Nursing, Yale University, Orange, Connecticut, USA, t.zhao@yale.edu.
Xiaolin ChangDepartment of Statistics, University of Connecticut, Storrs, Connecticut, USA.
Subrata Kumar BiswasDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Jeremy L BalsbaughProteomics and Metabolomics Facility, University of Connecticut, Storrs, Connecticut, USA.
Jennifer LiddleProteomics and Metabolomics Facility, University of Connecticut, Storrs, Connecticut, USA.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, Connecticut, USA.
Adam P MatsonDivision of Neonatology, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Nathan N AlderDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Xiaomei CongSchool of Nursing, Yale University, Orange, Connecticut, USA.
University of Connecticut · USConnecticut Children's Medical Center · USYale University · US

Funding

NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm InfantsR01NR016928 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2017 to 2020
$2.5M
Early Life Experience Imprints Gut Microbiome in Preterm InfantsK23NR014674 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2013 to 2015
$396k
Integrative omics analysis of pain/stress impact on mitochondrial function and neurodevelopment in preterm infantsF31NR019940 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI ZHAO, TINGTING · 2022 to 2022
$45k
NCATS NIH HHS TL1 TR001864NINR NIH HHS F31 NR019940NINR NIH HHS K23 NR014674NINR NIH HHS R01 NR016928
6 · The paper itself

Abstract

introductionPreterm infants experience tremendous early life pain/stress during their neonatal intensive care unit (NICU) hospitalization, which impacts their neurodevelopmental outcomes. Mitochondrial function/dysfunction may interface between perinatal stress events and neurodevelopment. Nevertheless, the specific proteins or pathways linking mitochondrial functions to pain-induced neurodevelopmental outcomes in infants remain unidentified. Our study aims to investigate the associations among pain/stress, proteins associated with mitochondrial function/dysfunction, and neurobehavioral responses in preterm infants.

methodsWe conducted a prospective cohort study, enrolling 33 preterm infants between September 2017 and July 2022 at two affiliated NICUs located in Hartford and Farmington, CT. NICU Network Neurobehavioral Scale (NNNS) datasets were evaluated to explore potential association with neurobehavioral outcomes. The daily pain/stress experienced by infant's during their NICU stay was documented. At 36-38 weeks post-menstrual age (PMA), neurobehavioral outcomes were evaluated using the NNNS and buccal swabs were collected for further analysis. Mass spectrometry-based proteomics was conducted on epithelial cells obtained from buccal swabs to evaluate protein expression level. Lasso statistical methods were conducted to study the association between protein abundance and infants' NNNS summary scores. Multiple linear regression and Gene Ontology (GO) enrichment analyses were performed to examine how clinical characteristics and neurodevelopmental outcomes may be associated with protein levels and underlying molecular pathways.

resultsDuring NICU hospitalization, preterm premature rupture of membrane (PPROM) was negatively associated with neurobehavioral outcomes. The protein functions including leptin receptor binding activity, glutathione disulfide oxidoreductase activity and response to oxidative stress, lipid metabolism, and phosphate and proton transmembrane transporter activity were negatively associated with neurobehavioral outcomes; in contrast, cytoskeletal regulation, epithelial barrier, and protection function were found to be associated with the optimal neurodevelopmental outcomes. In addition, mitochondrial function-associated proteins including SPRR2A, PAIP1, S100A3, MT-CO2, PiC, GLRX, PHB2, and BNIPL-2 demonstrated positive association with favorable neurodevelopmental outcomes, while proteins of ABLIM1, UNC45A, keratins, MUC1, and CYB5B showed positive association with adverse neurodevelopmental outcomes.

conclusionMitochondrial function-related proteins were observed to be associated with early life pain/stress and neurodevelopmental outcomes in infants. Large-scale studies with longitudinal datasets are warranted. Buccal proteins could be used to predict potential neurobehavioral outcomes.

Indexed as

Infant, PrematureChild DevelopmentFemaleHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMitochondriaPainProspective StudiesStress, PsychologicalMass spectrometryMitochondrial dysfunctionPain/stressPreterm infants

Identifiers

PMID38286121
PMCPMC11284246
OpenAlexW4392683165

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.