Evidence map›Paper›PMID 38285982›Full record

ArticleAnnals of internal medicine2024

Association of Low Glomerular Filtration Rate With Adverse Outcomes at Older Age in a Large Population With Routinely Measured Cystatin C.

Edouard L Fu, Juan-Jesus Carrero, Yingying Sang, Marie Evans, Junichi Ishigami, Lesley A Inker, Morgan E Grams, Andrew S Levey, Josef Coresh, Shoshana H Ballew

Open access · greenAbstract read
In one paragraph

Article in Annals of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Guideline
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  5. The kidney failure risk equation in people with CKD and multimorbidity: the effect of competing mortality risks.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Observational
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  13. High measured GFR as a predictor of all-cause mortality and cardiovascular disease in a prospective non-diabetic population cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Edouard L FuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands (E.L.F.).ORCID 0000-0002-9698-6825
Juan-Jesus CarreroDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, and Division of Nephrology, Department of Clinical Sciences, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden (J.-J.C.).ORCID 0000-0003-4763-2024
Yingying SangOptimal Aging Institute and Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, New York, New York (Y.S.).ORCID 0000-0002-6179-7864
Marie EvansDepartment of Clinical Intervention and Technology, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden (M.E.).ORCID 0000-0001-8650-5795
Junichi IshigamiDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland (J.I.).ORCID 0000-0002-6396-3723
Lesley A InkerDivision of Nephrology, Department of Internal Medicine, Tufts Medical Center, Boston, Massachusetts (L.A.I., A.S.L.).
Morgan E GramsDivision of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York (M.E.G.).ORCID 0000-0002-4430-6023
Andrew S LeveyDivision of Nephrology, Department of Internal Medicine, Tufts Medical Center, Boston, Massachusetts (L.A.I., A.S.L.).ORCID 0000-0003-1491-501X
Josef CoreshOptimal Aging Institute and Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, New York, New York, and Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland (J.C., S.H.B.).ORCID 0000-0002-4598-0669
Shoshana H BallewOptimal Aging Institute and Division of Epidemiology, Department of Population Health, New York University Grossman School of Medicine, New York, New York, and Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland (J.C., S.H.B.).ORCID 0000-0002-7547-3764
Johns Hopkins University · USNew York University · USTufts Medical Center · USBrigham and Women's Hospital · USKarolinska Institutet · SEKarolinska University Hospital · SE

Funding

Chronic Kidney Disease Prognosis Consortium (CKD-PC)R01DK100446 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, Morgan Erika Grams · 2014 to 2026
$10.7M
Medication Use and Adverse Events in CKDR01DK115534 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Alexander R Chang, Morgan Erika Grams · 2018 to 2026
$5.7M
Prevention and Treatment of Cardiovascular Disease in Patients with Chronic Kidney Disease: Patient-Oriented Research and Mentoring - RenewalK24HL155861 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Morgan Erika Grams · 2021 to 2026
$732k
Implementation research to improve the uptake of influenza vaccination in CKDK01DK125616 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ISHIGAMI, JUNICHI · 2021 to 2024
$628k
NHLBI NIH HHS K24 HL155861NIDDK NIH HHS K01 DK125616NIDDK NIH HHS R01 DK100446NIDDK NIH HHS R01 DK115534
6 · The paper itself

Abstract

backgroundThe commonly accepted threshold of glomerular filtration rate (GFR) to define chronic kidney disease (CKD) is less than 60 mL/min/1.73 m

objectiveTo evaluate associations in older adults between eGFR

designPopulation-based cohort study.

settingStockholm, Sweden, 2010 to 2019.

participants82 154 participants aged 65 years or older with outpatient creatinine and cystatin C testing. MEASUREMENTS: Hazard ratios for all-cause mortality, cardiovascular mortality, and kidney failure with replacement therapy (KFRT); incidence rate ratios for recurrent hospitalizations, infection, myocardial infarction or stroke, heart failure, and acute kidney injury.

resultsThe associations between eGFR LIMITATION: No GFR measurements.

conclusionCompared with low eGFR PRIMARY FUNDING SOURCE: Swedish Research Council, National Institutes of Health, and Dutch Kidney Foundation.

Indexed as

Cystatin CRenal Insufficiency, ChronicAgedCohort StudiesCreatinineGlomerular Filtration RateHumansKidneyCreatinineCystatin C

Identifiers

PMID38285982
PMCPMC11079939
OpenAlexW4391303288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.