Evidence map›Paper›PMID 38285948›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.

Walter R Mancia Leon, David M Steffen, Fiona R Dale-Huang, Benjamin Rakela, Arnar Breevoort, Ricardo Romero-Rodriguez, Andrea R Hasenstaub, Michael P Stryker, Joshua A Weiner, Arturo Alvarez-Buylla

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Walter R Mancia Leon *Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143.
David M Steffen *Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0002-4599-3005
Fiona R Dale-HuangDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143.
Benjamin RakelaDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94143.
Arnar BreevoortDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94143.
Ricardo Romero-RodriguezDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143.
Andrea R HasenstaubDepartment of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143.
Michael P StrykerDepartment of Physiology, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0003-1546-5831
Joshua A WeinerDepartment of Biology, The University of Iowa, Iowa City, IA 52242.
Arturo Alvarez-BuyllaDepartment of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0003-4426-8925
University of California, San Francisco · USUniversity of Iowa · US

Funding

NEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
DEVELOPMENT &PLASTICITY OF THE VISUAL SYSTEMR01EY002874 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STRYKER, MICHAEL P · 1986 to 2022
$6.4M
Elucidating Functions of the Gamma-Protocadherins in CNS Synapse DevelopmentR01NS055272 · NINDS · UNIVERSITY OF IOWA · PI WEINER, JOSHUA A · 2007 to 2020
$5.1M
Elucidating Novel Features of Visual Processing and Physiological Connectivity from Retina to Primary Visual CortexR01EY031059 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, Alexander C Huk · 2020 to 2026
$4.7M
Clustered protocadherin regulation of cortical interneuron survival circuit assembly and plasticityR01MH122478 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO, HASENSTAUB, ANDREA RAYNE · 2020 to 2024
$3.7M
CHARACTERIZATION OF NEURAL STEM CELLS IN THE ADULT BRAINR37NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 2000 to 2007
$2.9M
Cortical circuitry supporting flexible audiovisual interactions and behaviorsR01NS116598 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HASENSTAUB, ANDREA RAYNE · 2023 to 2024
$1.0M
Reducing Diversity at the Gamma Protocadherin Locus by CRISPR TargetingR21NS090030 · NINDS · JACKSON LABORATORY · PI BURGESS, ROBERT W., WEINER, JOSHUA A · 2014 to 2015
$506k
Elucidating Functions of the Gamma-Protocadherins in CNS DevelopmentR56NS055272 · NINDS · UNIVERSITY OF IOWA · PI WEINER, JOSHUA A · 2012 to 2012
$432k
Mechanisms of Transplanted Cortical Interneuron Survival and FunctionK99EY033976 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAKELA, BENJAMIN · 2022 to 2023
$235k
Functional Integration of Medial Ganglionic Eminence Interneuron Transplants into Visual CortexF32EY029935 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAKELA, BENJAMIN · 2019 to 2021
$196k
NCI NIH HHS T32 CA151022NEI NIH HHS F32 EY029935NEI NIH HHS K99 EY033976NEI NIH HHS R01 EY002874NEI NIH HHS R01 EY031059NIH HHS EY02517NIH HHS NS028478NIH HHS NS055272NIH HHS NS090030NIH HHS R01EY002874NIH HHS R01EY031059NIH HHS R01MH122478NIH HHS R01NS116598NIMH NIH HHS R01 MH122478NINDS NIH HHS R01 NS028478NINDS NIH HHS R01 NS055272NINDS NIH HHS R01 NS116598NINDS NIH HHS R21 NS090030NINDS NIH HHS R37 NS028478NINDS NIH HHS R56 NS055272
6 · The paper itself

Abstract

Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into the cortex where they make connections with locally produced excitatory glutamatergic neurons. Cortical function critically depends on the number of cINs, which is also key to establishing the appropriate inhibitory/excitatory balance. The final number of cINs is determined during a postnatal period of programmed cell death (PCD) when ~40% of the young cINs are eliminated. Previous work shows that the loss of clustered gamma protocadherins (Pcdhgs), but not of genes in the

Indexed as

InterneuronsProtocadherinsAnimalsApoptosisCerebral CortexHumansMiceNeuronsProtein IsoformsProtein IsoformsProtocadherinsGABAergicinhibitory neuronsmedial ganglionic eminenceneuronal eliminationtransplantation

Identifiers

PMID38285948
PMCPMC10861877
OpenAlexW4391304220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.