Evidence map›Paper›PMID 38285672›Full record

ArticlePloS one2024

Peripapillary vessel density in eyes with cone-rod dystrophy.

Masato Shinozuka, Mizuho Arai, Yumeno Hirayama, Yuna Uechi, Shohei Kawasaki, Kazuyoshi Okawa, Yume Iwashita, Misa Miyazato, Kazushi Hirono, Kentaro Nakamura and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Masato ShinozukaDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Mizuho AraiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Yumeno HirayamaDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Yuna UechiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Shohei KawasakiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Kazuyoshi OkawaDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Yume IwashitaDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Misa MiyazatoDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Kazushi HironoDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Kentaro NakamuraDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Tatsuya InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.ORCID 0000-0002-2481-0222
Ryo AsaokaDepartment of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Yasuo YanagiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Maiko Maruyama-InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Kazuaki KadonosonoDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Yokohama City University · JPSeirei Christopher University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compared the vessel density (VD) around the optic nerve head (ONH) in eyes with cone-rod dystrophy (CORD) and healthy control eyes in a sector-wise manner and to investigate the relationship between VD around the ONH and visual function in CORD eyes.

methodsTwenty-six eyes in 14 CORD patients and 25 eyes in 25 healthy control subjects were examined. Using OCT angiography images, the VDs in the superficial and deep capillary plexus at the macula (sVDm and dVDm) and those around the ONH in the superior, temporal, inferior and nasal region (VDnh_s, VDnh_t, VDnh_i, and VDnh_n, respectively) were measured for each eye. Patient age, visual acuity (VA) and VDs were then compared between two groups. Moreover, the relationships between VA and the VDs were analyzed using a linear mixed model and AICc model selection.

resultsNo significant difference in age was seen between the CORD and control groups (p = 0.87, Wilcoxon rank sum test), but the VA was significantly lower in the CORD group (p<0.0001). Both sVDm and dVDm were significantly lower in the CORD eyes than in the control eyes (both p<0.0001). Among VDnh_s, VDnh_t, VDnh_i, and VDnh_n, however, only VDnh_t differed significantly between the CORD and control groups (p = 0.035). Among age, VDnh_t, dVDm, and sVDm, the optimal model for VA included only VDnh_t and dVDm.

conclusionsIn addition to the VD in the deep capillary plexus at the macula, the measurement of temporal VD around the ONH might be useful for predicting visual function in eyes with CORD.

Indexed as

Cone-Rod DystrophiesOptic DiskFluorescein AngiographyHumansRetinal VesselsTomography, Optical Coherence

Identifiers

PMID38285672
PMCPMC10824446
OpenAlexW4391323893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.