Biochemical Markers for Liver Injury in Zebrafish Larvae.

Rafael Xavier Martins, Juliana Alves Costa Ribeiro Souza, Maria Eduarda Maia, Matheus Carvalho, Terezinha Souza, Davi Farias

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Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Rafael Xavier MartinsPost-Graduation Program in Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.

Juliana Alves Costa Ribeiro SouzaDepartment of Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil.

Maria Eduarda MaiaPost-Graduation Program in Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.

Matheus CarvalhoPost-Graduation Program in Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.

Terezinha SouzaPost-Graduation Program in Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil.

Davi FariasPost-Graduation Program in Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Brazil. davi@dbm.ufpb.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver plays a crucial role in detoxification processes and metabolism of xenobiotics, and therefore, it is a target organ of toxicity of different classes of chemicals. In this context, some key enzymes present in liver are considered to be good biochemical markers of hepatic damage and can have their activities determined via spectrophotometry. Aspartate and alanine aminotransferases, alkaline phosphatase, lactate dehydrogenase, and glutathione peroxidase are enzymes that have activities often changed in response to hepatotoxic compounds and can be accessed through the larval period of zebrafish (Danio rerio). In this chapter, we described methodologies for analyses of these five biomarkers in pooled zebrafish larvae through spectrophotometry.

Indexed as

PerciformesZebrafishAlanine TransaminaseAnimalsBiomarkersLarvaLiverAlanine TransaminaseBiomarkersBiochemical markersDrug-induced liver injuryHepatic diseasesLiver failure

Identifiers

PMID38285360

DOI10.1016/j.chemosphere.2016.11.004

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