Evidence map›Paper›PMID 38285287›Full record

ArticleMolecular neurobiology2024

Study on the Role and Mechanism of Exosomes Derived from Dental Pulp Stem Cells in Promoting Regeneration of Myelin Sheath in Rats with Sciatic Nerve Injury.

Ying Chai, Yuemin Liu, Zhiyang Liu, Wenbin Wei, Yabing Dong, Chi Yang, Minjie Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  10. Stem cell and gene therapies for leukodystrophies.Molecular therapy. Methods & clinical development · 2025
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  12. Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ying ChaiDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuemin LiuDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhiyang LiuDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenbin WeiDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yabing DongDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chi YangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yangchi1234@yeah.net.
Minjie ChenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chenminjie71@163.com.ORCID http://orcid.org/0000-0002-7747-6846

Funding

CAMS Innovation Fund for Medical Sciences（CIFMS） No.2019-I2M-5-037Interdisciplinary Program of Shanghai Jiao Tong University No.YG2022QN050Medical Innovation Research Project of Shanghai Science and Technology Commission 21Y11903500National Clinical Key Specialized Project Difficult Diseases in the OralNational Clinical Key Specialized Project InnovationNational Clinical Key Specialized Project Maxillofacial RegionsNational Clinical Key Specialized Project Practice of the Comprehensive Surgical DiagnosisNational Clinical Key Specialized Project Treatment for MajorShanghai Clinical Research Center for Oral Diseases No.19MC1910600Shanghai Municipal Key Clinical Specialty No.shslczdzk01601Shanghai's Top Priority Research Center No.2022ZZ01017
6 · The paper itself

Abstract

The prognosis of peripheral nerve injury (PNI) is usually poor, and currently, there is no effective treatment for PNI. Studies have shown that exosomes derived from mesenchymal stem cells could promote nerve regeneration by optimizing the function of endogenous Schwann cells (SCs), while the mechanism is unclear. Autophagy, a highly conserved intracellular catabolic process responsible for maintaining cellular homeostasis, has been proved to be involved in the regulation of nerve repair after injury. We explored the effect of exosomes derived from dental pulp stem cells (DPSC-Exos) on the regeneration of myelin sheath in rats with sciatic nerve injury (SNI). In vitro and in vivo experiments were performed to clarify whether the effect of DPSC-Exos is associated with autophagy of SCs and to reveal the mechanism at the molecular level. Our results showed that the SCs of SNI rats exhibited the obvious autophagic characteristics, and the increase of P53 expression was an internal factor of autophagy. Our mechanism research indicated that DPSC-Exos could deliver miR-122-5p from DPSCs into SCs and suppressed the rapamycin (RAPA)-induced autophagy in SCs by inhibiting P53 expression. Rescue experiments showed that both the use of GW4869 and overexpression of exogenous P53 in SCs could reverse the inhibitory effect of DPSCs on the autophagy in SCs from co-culture system. In short, our study indicated that DPSC-Exos could promote the regeneration of the myelin sheath through suppressing the autophagy in SCs caused by PNI via miR-122-5p/P53 pathway; this provides researchers with another option for precise repair of PNI.

Indexed as

AutophagyDental PulpExosomesMyelin SheathNerve RegenerationRats, Sprague-DawleySchwann CellsSciatic NerveStem CellsAniline CompoundsAnimalsBenzylidene CompoundsMaleMicroRNAsPeripheral Nerve InjuriesRatsAniline CompoundsBenzylidene CompoundsGW 4869MicroRNAsTumor Suppressor Protein p53AutophagyDPSC-ExosP53Peripheral nerve injurySchwann cells

Identifiers

PMID38285287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.