Evidence map›Paper›PMID 38284846›Full record

ArticleJournal of neuroscience research2024

Compartmentalized ciliation changes of oligodendrocytes in aged mouse optic nerve.

Ke Ning, Matthew Tran, Tia J Kowal, Louise A Mesentier-Louro, Brent E Sendayen, Qing Wang, Chien-Hui Lo, Tingting Li, Rishab Majumder, Jian Luo and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Primary Cilia of Astrocytes in the Retina in Development and Disease.Investigative ophthalmology & visual science · 2026
    Article
  2. PMToxics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ke NingDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.ORCID 0000-0001-8994-3803
Matthew TranDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Tia J KowalDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Louise A Mesentier-LouroDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Brent E SendayenDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Qing WangDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Chien-Hui LoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Tingting LiDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Rishab MajumderDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Jian LuoVeterans Administration Palo Alto Health Care System, Palo Alto, California, USA.
Yang HuDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Yaping Joyce LiaoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Yang SunDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Stanford University · USVA Palo Alto Health Care System · USIcahn School of Medicine at Mount Sinai · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Elucidating Neuron-Intrinsic Molecular Mechanisms of Optic Nerve RegenerationR01EY024932 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI Yang Hu · 2015 to 2026
$4.8M
Neuroprotection by Modulating ER Stress in GlaucomaR01EY023295 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI HU, YANG · 2013 to 2022
$3.8M
The role of primary cilia in glaucoma pathogenesisR01EY025295 · NEI · STANFORD UNIVERSITY · PI Yang Sun · 2016 to 2026
$3.5M
In Vivo Function and Metabolism Evaluation of Glaucomatous RGCs by Two-Photon Scanning Laser OphthalmologyR01EY034353 · NEI · STANFORD UNIVERSITY · PI Yang Hu, Hao F Zhang · 2023 to 2026
$2.7M
Optineurin dysfunction induces neurodegeneration in normal tension glaucoma by a novel molecular mechanismR01EY032518 · NEI · STANFORD UNIVERSITY · PI Yang Hu · 2022 to 2026
$2.7M
Developing Novel Neuroprotective Strategies for EAE/Optic NeuritisR01EY028106 · NEI · STANFORD UNIVERSITY · PI HU, YANG · 2018 to 2021
$1.9M
Phosphoinositide signaling in glaucoma: rescue strategies for Lowe syndromeR01EY032159 · NEI · STANFORD UNIVERSITY · PI SUN, YANG · 2021 to 2024
$1.6M
Glaucoma Pathogenesis of Oculocerebrorenal syndrome of LoweK08EY022058 · NEI · STANFORD UNIVERSITY · PI SUN, YANG · 2012 to 2016
$994k
Primary Cilia of Astrocytes in GlaucomaK99EY034932 · NEI · STANFORD UNIVERSITY · PI NING, KE VERONICA · 2023 to 2024
$248k
Shedding light on glaucoma: optogenetics regulation of ciliary phosphoinositidesI01CX001481 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI SUN, YANG · 2017 to 2025
–
CSRD VA I01 CX001481NEI NIH HHS K08 EY022058NEI NIH HHS K99 EY034932NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY023295NEI NIH HHS R01 EY024932NEI NIH HHS R01 EY025295NEI NIH HHS R01 EY028106NEI NIH HHS R01 EY032159NEI NIH HHS R01 EY032518NEI NIH HHS R01 EY034353NIH HHS K08-EY022058NIH HHS K99EY034932NIH HHS R01-EY-023295NIH HHS R01-EY024932NIH HHS R01-EY025295NIH HHS R01-EY032159NIH HHS R01-EY26877NIH HHS R01-EY28106
6 · The paper itself

Abstract

Primary cilia are microtubule-based sensory organelles that project from the apical surface of most mammalian cells, including oligodendrocytes, which are myelinating cells of the central nervous system (CNS) that support critical axonal function. Dysfunction of CNS glia is associated with aging-related white matter diseases and neurodegeneration, and ciliopathies are known to affect CNS white matter. To investigate age-related changes in ciliary profile, we examined ciliary length and frequency in the retinogeniculate pathway, a white matter tract commonly affected by diseases of aging but in which expression of cilia has not been characterized. We found expression of Arl13b, a marker of primary cilia, in a small group of Olig2-positive oligodendrocytes in the optic nerve, optic chiasm, and optic tract in young and aged C57BL/6 wild-type mice. While the ciliary length and ciliated oligodendrocyte cells were constant in young mice in the retinogeniculate pathway, there was a significant increase in ciliary length in the anterior optic nerve as compared to the aged animals. Morphometric analysis confirmed a specific increase in the ciliation rate of CC1

Indexed as

Optic NerveWhite MatterAnimalsMammalsMiceMice, Inbred C57BLNeurogliaOligodendrogliaaging eyeARL13Bmature oligodendrocytesoligodendrocyte progenitor cellsoptic nerveprimary cilia

Identifiers

PMID38284846
PMCPMC10827352
OpenAlexW4389097754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.