Evidence map›Paper›PMID 38284765›Full record

ReviewChemical communications (Cambridge, England)2024

Quantitative mass spectrometry imaging: therapeutics & biomolecules.

Joseph H Holbrook, Gabrielle E Kemper, Amanda B Hummon

Abstract readReview
In one paragraph

Review in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. High-Specificity and Sensitivity Imaging of Neutral Lipids Using Salt-Enhanced MALDI TIMS.Journal of the American Society for Mass Spectrometry · 2025
    Article
  11. Article
  12. Spatial mapping of phosphatidylcholineInternational journal of mass spectrometry · 2025
    Article
  13. Mass Spectrometry Imaging for Spatial Toxicology Research.Journal of mass spectrometry : JMS · 2024
    Review
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph H HolbrookOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA. hummon.1@osu.edu.
Gabrielle E KemperDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Amanda B HummonOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA. hummon.1@osu.edu.ORCID http://orcid.org/0000-0002-1969-9013

Funding

Spatial SILAC: Examining the Proteome in 3D Cell CulturesR01GM110406 · NIGMS · UNIVERSITY OF NOTRE DAME · PI HUMMON, AMANDA B. · 2014 to 2022
$3.0M
Electroblotting through enzymatic membranes to enhance MALDI tissue imaging of proteinsR21AG062144 · NIA · OHIO STATE UNIVERSITY · PI HUMMON, AMANDA B. · 2019 to 2020
$424k
NIA NIH HHS R21 AG062144NIGMS NIH HHS R01 GM110406
6 · The paper itself

Abstract

Mass spectrometry imaging (MSI) has become increasingly utilized in the analysis of biological molecules. MSI grants the ability to spatially map thousands of molecules within one experimental run in a label-free manner. While MSI is considered by most to be a qualitative method, recent advancements in instrumentation, sample preparation, and development of standards has made quantitative MSI (qMSI) more common. In this feature article, we present a tailored review of recent advancements in qMSI of therapeutics and biomolecules such as lipids and peptides/proteins. We also provide detailed experimental considerations for conducting qMSI studies on biological samples, aiming to advance the methodology.

Indexed as

PeptidesProteinsDiagnostic ImagingMass SpectrometrySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationPeptidesProteins

Identifiers

PMID38284765
PMCPMC10878071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.