ArticleCurrent medicinal chemistry2025
Effect of Chitosan Coating on Drug Carrier Capacity of Metal-organic Framework MIL-100(Fe) Contained Cyclophosphamide.
Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAmong the various investigated drug carriers, metal-organic frameworks (MOFs) have recently gained attention due to their ability to adsorb different drugs and compatibility with various surface modification strategies. In this study, molecular dynamic simulation was conducted to assess the effect of chitosan on the loading of cyclophosphamide into MIL-100(Fe).
methodsThe simulations provided insights into atomic interactions by determining the coefficient of diffusion as mean squared displacement (MSD), resulting in values of 1.35 and 1.25 before and after chitosan coating, respectively. Experimental analysis of the chitosan- coated MIL-100(Fe) containing cyclophosphamide (MIL-100(Fe)/CS/CP) was performed using SEM, FTIR, BET, DLS, and powder X-ray diffraction. The drug loading and release processes were evaluated using UV-spectroscopy.
result
conclusionDLS analysis revealed that the presence of chitosan increased the particle size of MIL-100(Fe) from 381 to 463 nm and altered the zeta potential from 18 to -17 mV. The toxic impact of MIL-100(Fe)/CS/CP was evaluated on MCF-7 cells (human breast cancer cells) through
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