Evidence map›Paper›PMID 38284721›Full record

ArticleCurrent medicinal chemistry2025

Time Course of Biochemical and Metabolic Parameters During and After COVID-19.

Zohreh-Al-Sadat Ghoreshi, Mojtaba Abbasi-Jorjandi, Gholamreza Asadikaram, Mohsen Sharif-Zak, Mohammad Khaksari Haddad, Ali Afgar, Nasir Arefinia, Shahriar Dabiri, Clifford Rosen

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Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Zohreh-Al-Sadat GhoreshiResearch Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Mojtaba Abbasi-JorjandiDepartment of Biochemistry, Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Gholamreza AsadikaramDepartment of Biochemistry, Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.ORCID 0000-0002-9100-0756
Mohsen Sharif-ZakDepartment of Clinical Biochemistry, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad Khaksari HaddadPhysiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Ali AfgarDepartment of Parasitology and Mycology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Nasir ArefiniaDepartment of Biochemistry, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
Shahriar DabiriDepartment of Pathology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Clifford RosenDepartment of MaineHealth, MaineHealth Institue for Research, Scarborough, Maine, 04074, USA.
Kerman University of Medical Sciences · IRUniversity of Jiroft · IRMaineHealth · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong COVID is characterized by the persistence of symptoms among individuals who are infected with the SARS-CoV-2 virus. The enduring impact of these long-term effects on the health and well-being of those affected cannot be denied.

methods470 patients with SARS-CoV-2 were consecutively recruited in this longitudinal study. The participants were entered into moderate, severe, and critical groups. 235 out of 470 participants were female. The levels of fasting blood sugar (FBS), alanine transaminase (SGPT), aspartate aminotransferase (SGOT), alkaline phosphatase (ALP), creatinine (Cr), urea, uric acid (UA), and total protein (TP) were measured during hospitalization and again at one and three months after infection. The levels of Zn and hemoglobin A1c (HbA1c) were also measured only during hospitalization.

resultsCOVID-19 severity was associated with high levels of glucose, urea, Cr, ALT, AST, ALP, and HbA1c, and low levels of Zn, UA, and TP. There were significant sex differences for these markers at all three-time points. Glucose, urea, Cr, ALT, AST, and ALP all decreased three months after infection, whereas the levels of UA and TP returned towards normal.

conclusionCOVID-19 infection affects the levels of multiple biochemical factors in a gender-dependent manner. The biochemical changes become more tangible with increasing disease severity, and several of these predict mortality. Levels begin to return to normal after the acute phase of the disease, but in some individuals, at three months, several markers were still not within the normal range. Whether the trajectory of these changes can predict long COVID requires further testing.

Indexed as

COVID-19AdultAgedAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBiomarkersBlood GlucoseCreatinineFemaleGlycated HemoglobinHumansLongitudinal StudiesMaleMiddle AgedSARS-CoV-2Alanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBiomarkersBlood GlucoseCreatinineGlycated HemoglobinUreaUric Acidbiochemical factorsCOVID-19long-COVIDmetabolic parameters.post-COVIDSARS-CoV-2

Identifiers

PMID38284721
OpenAlexW4391322433

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.