ArticleCurrent computer-aided drug design2025
Designing Drug Delivery Vehicles based on N-(2-Hydroxypropyl) Methacrylamide.
Article in Current computer-aided drug design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nanoparticles as Drug Delivery Carrier-synthesis, Functionalization and Application.Current pharmaceutical design · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe development of polymeric-based drug delivery has seen faster growth in the past two decades. In polymers, copolymers are utilized as drug carriers to decrease the side effects and dosage-related toxicity.
objectivesThe primary objective of the study is to utilize computational resources to design drug molecules and perform
methodsDifferent functional groups were selected for attaching to the side chain of the copolymers through a random trial and error approach. In order to predict the pharmacokinetic properties (absorption, distribution, metabolism, excretion, and toxicity), the designed copolymer molecules were evaluated utilizing Swiss ADME and pkCSM pharmacokinetics servers. Molecular interaction between the designed copolymer molecules and human serum albumin was performed using AutoDock Vina and PatchDock server.
resultsThe designed molecules are shown to be soluble in water and have high gastrointestinal absorption. Only one molecule is predicted to pass through the blood-brain barrier. Two designed molecules have been shown to have carcinogenic properties. Lethal dose 50, cytochrome P450, and permeability glycoprotein substrate formation were also analyzed for toxicity and metabolism.
conclusionOur study will provide insight for designing new drug compounds or carriers and analyzing their physicochemical properties to further optimize compounds for clinical studies.
Indexed as
Identifiers
38284714What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.