Evidence map›Paper›PMID 38284649›Full record

ArticleGut microbes

Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model.

Shivdeep S Hayer, Mackenzie Conrin, Jeffrey A French, Andrew K Benson, Sophie Alvarez, Kathryn Cooper, Anne Fischer, Zahraa Wajih Alsafwani, William Gasper, Mallory J Suhr Van Haute and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Shivdeep S HayerDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Mackenzie ConrinDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Jeffrey A FrenchCallitrichid Research Center, University of Nebraska at Omaha, Omaha, NE, USA.
Andrew K BensonNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, USA.
Sophie AlvarezProteomics and Metabolomics Facility, Nebraska Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Kathryn CooperSchool of Interdisciplinary Informatics, College of Information Science and Technology, University of Nebraska at Omaha, Omaha, NE, USA.
Anne FischerProteomics and Metabolomics Facility, Nebraska Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Zahraa Wajih AlsafwaniSchool of Interdisciplinary Informatics, College of Information Science and Technology, University of Nebraska at Omaha, Omaha, NE, USA.
William GasperSchool of Interdisciplinary Informatics, College of Information Science and Technology, University of Nebraska at Omaha, Omaha, NE, USA.
Mallory J Suhr Van HauteNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, USA.
Haley R HassenstabDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Shayda AzadmaneshDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Missy BriardyDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Skyler GerbersDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Aliyah JabenisDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Jennifer L ThompsonDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
Jonathan B ClaytonDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.ORCID 0000-0003-3709-3362
University of Nebraska at Omaha · USUniversity of Nebraska–Lincoln · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
A Model of Antibiotic-induced Gut Dysbiosis and Depressive SymptomatologyK01OD030514 · OD · UNIVERSITY OF NEBRASKA OMAHA · PI Jonathan Brent Clayton · 2022 to 2026
$634k
E-PACERR: ENHANCING PROFESSIONALISM, ADVOCACY, AND CAPACITY FOR EXCELLENCE IN RESPONSIBLE BIOINFORMATICS RESEARCHR25GM141506 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI COOPER, KATHRYN M · 2021 to 2023
$262k
NCI NIH HHS P30 CA036727NIGMS NIH HHS P20 GM103427NIGMS NIH HHS R25 GM141506NIH HHS K01 OD030514
6 · The paper itself

Abstract

Emerging evidence indicates that antibiotic-induced dysbiosis can play an etiological role in the pathogenesis of neuropsychiatric disorders. However, most of this evidence comes from rodent models. The objective of this study was to evaluate if antibiotic-induced gut dysbiosis can elicit changes in gut metabolites and behavior indicative of gut-brain axis disruption in common marmosets (

Indexed as

Anti-Bacterial AgentsGastrointestinal MicrobiomeAnimalsBrain-Gut AxisCallithrixDysbiosisHumansMultiomicsAnti-Bacterial AgentsantimicrobialscortisolGut–microbiota–brain axismetabolomemicrobiome-metabolome-correlationpsychiatrystress reactivity

Identifiers

PMID38284649
PMCPMC10826635
OpenAlexW4391315319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.