Evidence map›Paper›PMID 38284555›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings.

Hanna Huber, Kaj Blennow, Henrik Zetterberg, Mercé Boada, Andreas Jeromin, Haley Weninger, Raul Nuñez-Llaves, Núria Aguilera, Maribel Ramis, Joel Simrén and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  4. Substituting blood-based biomarkers for imaging measures in Alzheimer's disease studies: implications for sample size and bias.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  16. Down syndrome in Africa: Challenges, opportunities, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  17. Article
  18. Global multi-specialty clinician perspectives on the implementation of Alzheimer's disease blood biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 5 countries.

Hanna HuberDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Mercé BoadaNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Andreas JerominALZ Path Inc., Carlsbad, California, USA.
Haley WeningerDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Raul Nuñez-LlavesAce Alzheimer Center Barcelona, International University of Catalunya (UIC), Barcelona, Spain.
Núria AguileraAce Alzheimer Center Barcelona, International University of Catalunya (UIC), Barcelona, Spain.
Maribel RamisAce Alzheimer Center Barcelona, International University of Catalunya (UIC), Barcelona, Spain.
Joel SimrénDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Johanna NilssonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Juan Lantero-RodriguezDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Adelina OrellanaAce Alzheimer Center Barcelona, International University of Catalunya (UIC), Barcelona, Spain.
Fernando García-GutiérrezAce Alzheimer Center Barcelona, International University of Catalunya (UIC), Barcelona, Spain.
Xavier MoratóNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
Laia Montoliu-GayaDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Shagreens Academy at the University of Gothenburg, Mölndal, Sweden.
University of Gothenburg · SEUniversitat Internacional de Catalunya · ESInstituto de Salud Carlos III · ESKing's College London · GBSahlgrenska University Hospital · SEStructural Analytics (United States) · USUniversity of Wisconsin–Madison · US

Funding

AD Strategic Fund and the Alzheimer's Association ADSF-21-831376-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831377-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831381-CAD Strategic Fund and the Alzheimer's Association ADSF-24-1284328-CAlzheimer Drug Discovery Foundation 201809-2016862Alzheimerfonden AF-981227Alzheimer's Association 2021 Zenith ZEN-21-848495Alzheimer's Association 2022-2025 2019-02397Alzheimer's Association 2022-2025 2022-01018Alzheimer's Association 2022-2025 SG-23-1038904 QCCare Research University College London Hospitals Biomedical Research CentreEuropean Union Joint Program for Neurodegenerative Disorders JPND2019-466-236European Union Joint Program - Neurodegenerative Disease Research JPND2021-00694European Union's Horizon Europe research and innovation program 101053962National Institute for HealthSwedish Alzheimer Foundation AF-930351Swedish Alzheimer Foundation AF-939721Swedish Alzheimer Foundation AF-968270Swedish Hjärnfonden ALZ2022-0006Swedish Hjärnfonden FO2017-0243Swedish Research Council 2017-00915Swedish Research Council 2022-00732Swedish State Support for Clinical Research ALFGBG-71320UK Dementia Research Institute UKDRI-1003
6 · The paper itself

Abstract

backgroundWe aimed to evaluate the precision of Alzheimer's disease (AD) and neurodegeneration biomarker measurements from venous dried plasma spots (DPS

methodsIn a discovery (n = 154) and a validation cohort (n = 115), glial fibrillary acidic protein (GFAP); neurofilament light (NfL); amyloid beta (Aβ) 40, Aβ42; and phosphorylated tau (p-tau181 and p-tau217) were measured in paired DPS

resultsAll DPS DISCUSSION: Our data suggest that measuring blood biomarkers related to AD pathology and neurodegeneration from DPS HIGHLIGHTS: A wide array of biomarkers related to Alzheimer's disease (AD) and neurodegeneration were detectable in dried plasma spots (DPS

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloidogenic ProteinsBiomarkersHumansPlasmatau ProteinsAmyloid beta-PeptidesAmyloidogenic ProteinsBiomarkerstau ProteinsAlzheimer's diseaseamyloid betabiomarkersblooddried blood spotsdried plasma spotsglial fibrillary acidic proteinneurodegenerationneurofilament lightphosphorylated tauplasmaremote samplingtemperature‐independent sampling

Identifiers

PMID38284555
PMCPMC11032540
OpenAlexW4391315711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.