Evidence map›Paper›PMID 38284460›Full record

ArticleBasic & clinical pharmacology & toxicology2024

Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice.

Mackenzie Newman, Cayla Lynch, Heather Connery, William Goldsmith, Timothy Nurkiewicz, Raymond Raylman, Jonathan Boyd

Open access · hybridAbstract read
In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mackenzie NewmanDepartment of Orthopaedic Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Cayla LynchDepartment of Physiology, Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA.
Heather ConneryDepartment of Physiology, Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA.
William GoldsmithDepartment of Physiology, Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA.
Timothy NurkiewiczDepartment of Physiology, Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, USA.
Raymond RaylmanDepartment of Radiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Jonathan BoydDepartment of Orthopaedic Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-7023-9979
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
Pre-doctoral Training in Systems ToxicologyT32ES032920 · NIEHS · WEST VIRGINIA UNIVERSITY · PI Timothy R Nurkiewicz · 2022 to 2026
$1.2M
NIEHS NIH HHS R01 ES015022NIEHS NIH HHS T32 ES032920NIGMS NIH HHS P20 GM103434NIGMS NIH HHS U54 GM104942NIH HHS P20 GM103434NIH HHS R01 ES015022 (TRN)NIH HHS WV-CTSI U54 GM104942NIH HHS WV-INBRE
6 · The paper itself

Abstract

Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, with subjects monitored post-administration using pulse oximetry (5 min) and then whole-body plethysmography (40 min). Following the determination of subcutaneous dose-response, [18F]Fluorodeoxyglucose positron emission tomography (

Indexed as

Drug OverdoseFluorodeoxyglucose F18Analgesics, OpioidAnimalsFentanylHumansMicePositron-Emission TomographyPrognosisAnalgesics, OpioidFentanylFluorodeoxyglucose F18fentanylopioidoverdoseSKH1 mousewooden chest syndrome

Identifiers

PMID38284460
PMCPMC10939806
OpenAlexW4391322630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.