ArticleChemical communications (Cambridge, England)2024
Improving electrochemical hybridization assays with restriction enzymes.
Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Polymer Coating for the Long-Term Storage of Immobilized DNA.ACS sensors · 2025Article
- Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites.Analytical chemistry · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Nucleic acids in blood are early indicators of disease that could be detected by point-of-care biosensors if sufficiently sensitive and facile sensors existed. Electrochemical hybridization assays are sensitive and specific but are limited to very short nucleic acids. We have developed a restriction enzyme-assisted electrochemical hybridization (REH) assay for improved nucleic acid detection. By incorporating target-specific restriction enzymes, we detect long nucleic acids, with performance dependent on the location of the cut site relative to the electrode surface. Thus, we have further established guidelines for REH design to serve as a generalizable platform for robust electrochemical detection of long nucleic acids.
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