ArticleACS omega2024
Construction of Peptide-Lipoic Acid Cationic Polymers with Redox Responsiveness and Low Toxicity for Gene Delivery.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Closed-Loop Recyclable Solid Polymer Electrolytes via Dynamic Lipoate Cross-Linking.Angewandte Chemie (International ed. in English) · 2026Article
- Epigenetic modulation of the JAK2-STAT3 signaling pathway in osteoporosis: non-coding RNA networks as therapeutic targets.Journal of translational medicine · 2026Review
- Stimuli-Responsive Hydrogels: From Swelling-Deswelling Mechanisms to Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Next-generation miRNA therapeutics: from computational design to translational engineering.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As gene therapy continues to evolve, the development of safe and effective cationic polymer carriers is critical. In this work, three polymers have been prepared by ring-opening polymerization on the basis of peptide-lipoic acid monomers. By adjusting the sequence of the peptides, redox-responsive cationic polymers with different positive charge numbers were obtained, as well as investigating their performance as gene carriers. The results showed that the polymers complexed with negatively charged genes by electrostatic interaction and successfully transported the genes into the cells, additionally degrading and releasing the genes under glutathione (GSH) conditions. Furthermore, the polymers as gene carriers in different cell lines demonstrated lower cytotoxicity, with an excellent cell survival rate of 8 times higher than the "gold standard" polyethylenimine (PEI) at the same concentration. In vitro transfection experiments showed that the polymers successfully released and transfected genes into cells, demonstrating their immense potential in gene therapy.
Identifiers
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Registered trials
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